PMID- 12543794
OWN - NLM
STAT- MEDLINE
DCOM- 20030313
LR  - 20061115
IS  - 0008-5472 (Print)
IS  - 0008-5472 (Linking)
VI  - 63
IP  - 2
DP  - 2003 Jan 15
TI  - Association between human leukocyte antigen polymorphism and human papillomavirus 
      16-positive vulval intraepithelial neoplasia in British women.
PG  - 400-3
AB  - Polymorphisms in human leukocyte antigen (HLA) genes have been implicated in the 
      risk for developing human papillomavirus (HPV)-associated cervical neoplasia. By 
      comparison with local cadaver controls typed for HLA class I (n = 946) and II (n 
      = 144) antigens, HPV-16-positive high grade vulval intraepithelial neoplasia 
      patients (n = 42) showed significantly different frequencies of HLA-A2 [odds 
      ratio (OR), 2.1; confidence interval (CI), 1.4-3.9], HLA-B7 (OR, 2.6; CI, 
      1.4-4.7), HLA-DRB1*01(01/02/04) (OR, 0.1; CI, 0.03-0.5), HLA-DRB1*11 (OR, 3.3; 
      CI, 1.4-7.1), HLA-DRB1*13 (OR, 0), HLA-DQB1*05 (OR, 0.2; CI, 0.05-0.6), and 
      HLA-DQB1*03032 (OR, 4.6; CI, 1.5-14.0). With the exception of HLA-B7 and 
      HLA-DRB1*11, these significant differences were also seen comparative to local 
      HPV-16-positive cervical carcinoma patients (n = 114), suggesting a specific 
      immunogenetic contribution that is independent of HPV-16 infection in high-grade 
      vulval intraepithelial neoplasia. Such factors are important to the development 
      of HPV vaccines for treatment of cervical and vulval neoplasia.
FAU - Davidson, Emma J
AU  - Davidson EJ
AD  - Immunology Group, Paterson Institute for Cancer Research, Christie Hospital NHS 
      Trust, Manchester M20 4BX, United Kingdom.
FAU - Davidson, Judith A
AU  - Davidson JA
FAU - Sterling, Jane C
AU  - Sterling JC
FAU - Baldwin, Peter J W
AU  - Baldwin PJ
FAU - Kitchener, Henry C
AU  - Kitchener HC
FAU - Stern, Peter L
AU  - Stern PL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Res
JT  - Cancer research
JID - 2984705R
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Biopsy
MH  - Female
MH  - HLA-A Antigens/*genetics
MH  - HLA-DR Antigens/*genetics
MH  - Humans
MH  - Papillomaviridae/*classification
MH  - Papillomavirus Infections/genetics/*immunology/pathology
MH  - Polymorphism, Genetic
MH  - Tumor Virus Infections/genetics/*immunology/pathology
MH  - Vulvar Neoplasms/genetics/*immunology/pathology/*virology
EDAT- 2003/01/25 04:00
MHDA- 2003/03/14 04:00
CRDT- 2003/01/25 04:00
PHST- 2003/01/25 04:00 [pubmed]
PHST- 2003/03/14 04:00 [medline]
PHST- 2003/01/25 04:00 [entrez]
PST - ppublish
SO  - Cancer Res. 2003 Jan 15;63(2):400-3.