PMID- 12546682
OWN - NLM
STAT- MEDLINE
DCOM- 20031110
LR  - 20211203
IS  - 0300-5127 (Print)
IS  - 0300-5127 (Linking)
VI  - 31
IP  - Pt 1
DP  - 2003 Feb
TI  - A possible role for AMP-activated protein kinase in exercise-induced glucose 
      utilization: insights from humans and transgenic animals.
PG  - 186-90
AB  - Exercise-induced glucose uptake in skeletal muscle is mediated by an 
      insulin-independent mechanism, but the actual signals to glucose transport in 
      response to muscle contraction have not been identified. The 5'-AMP-activated 
      protein kinase (AMPK) has emerged as a putative mediator of contraction-induced 
      glucose transport, although no conclusive evidence has been provided so far. 
      Recent experiments in AMPK transgenic mice suggest that glucose transport induced 
      by 5-amino-4-imidazolecarboxamide riboside (AICAR) or hypoxia is mediated by 
      AMPK. In contrast, contraction-induced glucose transport in rodent skeletal 
      muscle induced by electrical stimulation in vitro or in situ is not influenced or 
      is only partially reduced by abolishing both or one of the catalytic AMPK 
      subunits. This is compatible with exercise studies done in humans, where no tight 
      correlation is found between AMPK activity and glucose uptake during exercise. 
      Taken together, these results question an essential role of AMPK in 
      exercise-induced glucose uptake and imply that one or more additional pathways 
      are involved in mediating glucose transport in skeletal muscle during exercise.
FAU - Nielsen, J N
AU  - Nielsen JN
AD  - Copenhagen Muscle Research Centre, Institute of Exercise and Sports Sciences, 
      Department of Human Physiology, University of Copenhagen, Denmark. 
      jnnielsen@aki.ku.dk
FAU - Jorgensen, S B
AU  - Jorgensen SB
FAU - Frosig, C
AU  - Frosig C
FAU - Viollet, B
AU  - Viollet B
FAU - Andreelli, F
AU  - Andreelli F
FAU - Vaulont, S
AU  - Vaulont S
FAU - Kiens, B
AU  - Kiens B
FAU - Richter, E A
AU  - Richter EA
FAU - Wojtaszewski, J F P
AU  - Wojtaszewski JF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Biochem Soc Trans
JT  - Biochemical Society transactions
JID - 7506897
RN  - 0 (Multienzyme Complexes)
RN  - 0 (Ribonucleotides)
RN  - 360-97-4 (Aminoimidazole Carboxamide)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - EC 2.7.11.31 (AMP-Activated Protein Kinases)
RN  - F0X88YW0YK (AICA ribonucleotide)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - AMP-Activated Protein Kinases
MH  - Aminoimidazole Carboxamide/*analogs & derivatives/pharmacology
MH  - Animals
MH  - Animals, Genetically Modified
MH  - Biological Transport
MH  - *Exercise
MH  - Glucose/*metabolism
MH  - Humans
MH  - Hypoxia
MH  - Models, Biological
MH  - Multienzyme Complexes/*physiology
MH  - Muscle, Skeletal/metabolism
MH  - Phosphorylation
MH  - *Physical Conditioning, Animal
MH  - Protein Serine-Threonine Kinases/*physiology
MH  - Ribonucleotides/pharmacology
MH  - Signal Transduction
RF  - 49
EDAT- 2003/01/28 04:00
MHDA- 2003/11/11 05:00
CRDT- 2003/01/28 04:00
PHST- 2003/01/28 04:00 [pubmed]
PHST- 2003/11/11 05:00 [medline]
PHST- 2003/01/28 04:00 [entrez]
AID - 10.1042/bst0310186 [doi]
PST - ppublish
SO  - Biochem Soc Trans. 2003 Feb;31(Pt 1):186-90. doi: 10.1042/bst0310186.