PMID- 12547708
OWN - NLM
STAT- MEDLINE
DCOM- 20030411
LR  - 20181113
IS  - 0002-9440 (Print)
IS  - 1525-2191 (Electronic)
IS  - 0002-9440 (Linking)
VI  - 162
IP  - 2
DP  - 2003 Feb
TI  - Altered pattern of major histocompatibility complex expression in renal 
      carcinoma: tumor-specific expression of the nonclassical human leukocyte 
      antigen-G molecule is restricted to clear cell carcinoma while up-regulation of 
      other major histocompatibility complex antigens is primarily distributed in all 
      subtypes of renal carcinoma.
PG  - 501-8
AB  - Renal epithelial cancers represent a heterogeneous group of neoplasms arising 
      from the malignant transformation of presumed diverse cell lineages. We recently 
      demonstrated that tumor-specific up-regulation of human leukocyte antigen 
      (HLA)-G, a nonclassical HLA class Ib molecule that might be involved in immune 
      evasion by tumor cells, frequently occurs in conventional (clear cell) renal 
      carcinoma. We here examined whether HLA-G activation is a common process 
      affecting all types of renal epithelial tumors. We analyzed a series of 38 
      paraffin-embedded tumors including clear cell, papillary, chromophobe, collecting 
      duct carcinoma, and oncocytoma. Seven of 12 (58%) clear cell tumors were positive 
      by immunohistochemistry, whereas all of the other subtypes of renal carcinoma 
      were negative for HLA-G expression. Developing or adult normal renal tissue were 
      devoid of HLA-G expression. We also observed that ectopic expression of HLA class 
      II antigens occurs more frequently in clear cell renal carcinoma than in other 
      subtypes of renal tumors. Moreover, in contrast to the common observation of a 
      down-regulation of major histocompatibility complex class Ia antigens reported in 
      various tumors, the concomitant study of the same biopsies for classical HLA 
      class Ia antigen expression revealed a general increase of HLA class Ia 
      expression, regardless of histological subtypes. These results provide evidence 
      for the heterogeneity of major histocompatibility complex expression patterns in 
      renal carcinoma and support the hypothesis that specific mechanisms underlying 
      the malignant transformation into clear cell renal carcinoma up-regulate 
      expression of HLA-G and to a lesser extent HLA class II molecule expression. 
      Considering the immunotolerant role of HLA-G toward the immune response, these 
      mechanisms may thus provide renal cell carcinoma tumor cells with additional 
      means to escape immune surveillance.
FAU - Ibrahim, El Cherif
AU  - Ibrahim EC
AD  - Service d'Anatomie Pathologique, INSERM U489, Hopital Tenon, Assistance 
      Publique-Hopitaux de Paris, Paris, France.
FAU - Allory, Yves
AU  - Allory Y
FAU - Commo, Frederic
AU  - Commo F
FAU - Gattegno, Bernard
AU  - Gattegno B
FAU - Callard, Patrice
AU  - Callard P
FAU - Paul, Pascale
AU  - Paul P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Pathol
JT  - The American journal of pathology
JID - 0370502
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-D Antigens)
RN  - 0 (HLA-DP Antigens)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Adenocarcinoma, Clear Cell/*genetics/immunology/pathology
MH  - Carcinoma, Renal Cell/*genetics/immunology/pathology
MH  - Gene Expression Regulation, Neoplastic/immunology
MH  - HLA Antigens/genetics
MH  - HLA-D Antigens/genetics
MH  - HLA-DP Antigens/genetics
MH  - HLA-G Antigens
MH  - Histocompatibility Antigens Class I/genetics
MH  - Humans
MH  - Kidney Neoplasms/*genetics/immunology/pathology
MH  - Major Histocompatibility Complex/*genetics
PMC - PMC1851152
EDAT- 2003/01/28 04:00
MHDA- 2003/04/12 05:00
PMCR- 2003/08/01
CRDT- 2003/01/28 04:00
PHST- 2003/01/28 04:00 [pubmed]
PHST- 2003/04/12 05:00 [medline]
PHST- 2003/01/28 04:00 [entrez]
PHST- 2003/08/01 00:00 [pmc-release]
AID - S0002-9440(10)63844-8 [pii]
AID - 3507 [pii]
AID - 10.1016/S0002-9440(10)63844-8 [doi]
PST - ppublish
SO  - Am J Pathol. 2003 Feb;162(2):501-8. doi: 10.1016/S0002-9440(10)63844-8.