PMID- 12548351
OWN - NLM
STAT- MEDLINE
DCOM- 20030328
LR  - 20161124
IS  - 1590-1874 (Print)
IS  - 1590-1874 (Linking)
VI  - 23 Suppl 2
DP  - 2002 Sep
TI  - Noradrenergic loss enhances MDMA toxicity and induces ubiquitin-positive striatal 
      whorls.
PG  - S75-6
AB  - Movement disorders involve a number of neurodegenerative conditions, mostly 
      affecting basal ganglia. Parkinson's disease (PD) is classically defined by the 
      selective loss of dopaminergic neurons in the substantia nigra pars compacta. 
      Administration of specific neurotoxins represents a common tool to reproduce this 
      lesion. Among these, amphetamine derivatives act as powerful monoamine 
      neurotoxins, impairing striatal dopamine (DA) axons in mice. Despite the 
      well-investigated effects on striatal DA terminals, only sporadic studies have 
      focused on the potential toxicity of amphetamines towards post-synaptic neurons 
      within the striatum. In the present work we found that 
      3,4-methylenedioxymethamphetamine (MDMA) produces ultrastructural alterations in 
      striatal cells, featuring as membraneous whorls, positive for ubiquitin and heat 
      shock protein 70. These morphological alterations were enhanced in locus 
      coeruleus-lesioned mice.
FAU - Ferrucci, M
AU  - Ferrucci M
AD  - Department of Human Morphology and Applied Biology, University of Pisa, Via Roma 
      55, I-56126 Pisa, Italy.
FAU - Gesi, M
AU  - Gesi M
FAU - Lenzi, P
AU  - Lenzi P
FAU - Soldani, P
AU  - Soldani P
FAU - Ruffoli, R
AU  - Ruffoli R
FAU - Pellegrini, A
AU  - Pellegrini A
FAU - Ruggieri, S
AU  - Ruggieri S
FAU - Paparelli, A
AU  - Paparelli A
FAU - Fornai, F
AU  - Fornai F
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Neurol Sci
JT  - Neurological sciences : official journal of the Italian Neurological Society and 
      of the Italian Society of Clinical Neurophysiology
JID - 100959175
RN  - 0 (Adrenergic Uptake Inhibitors)
RN  - 0 (HSP70 Heat-Shock Proteins)
RN  - 0 (Ubiquitin)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Adrenergic Uptake Inhibitors/*toxicity
MH  - Animals
MH  - Corpus Striatum/*drug effects/*metabolism/pathology
MH  - HSP70 Heat-Shock Proteins/metabolism
MH  - Locus Coeruleus/surgery
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Microscopy, Electron
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*toxicity
MH  - Neurons/diagnostic imaging/*drug effects/*metabolism
MH  - Norepinephrine/*deficiency
MH  - Ubiquitin/*metabolism
MH  - Ultrasonography
EDAT- 2003/01/28 04:00
MHDA- 2003/03/29 05:00
CRDT- 2003/01/28 04:00
PHST- 2003/01/28 04:00 [pubmed]
PHST- 2003/03/29 05:00 [medline]
PHST- 2003/01/28 04:00 [entrez]
AID - 10.1007/s100720200077 [doi]
PST - ppublish
SO  - Neurol Sci. 2002 Sep;23 Suppl 2:S75-6. doi: 10.1007/s100720200077.