PMID- 12548361
OWN - NLM
STAT- MEDLINE
DCOM- 20030328
LR  - 20041117
IS  - 1590-1874 (Print)
IS  - 1590-1874 (Linking)
VI  - 23 Suppl 2
DP  - 2002 Sep
TI  - Cytogenetic alterations in lymphocytes of Alzheimer's disease and Parkinson's 
      disease patients.
PG  - S97-8
AB  - We investigated the presence of cytogenetic alterations in peripheral blood 
      lymphocytes of Alzheimer's disease (AD) and Parkinson's disease (PD) patients. 
      Detection of spontaneous structural and/or numerical chromosome damage has been 
      assessed by micronucleus (MN) assay coupled with fluorescence in situ 
      hybridization (FISH). The cytogenetic investigation was performed on 22 AD 
      patients, 18 PD patients, and 20 controls. The spontaneous frequencies of 
      micronuclei (MN) in human lymphocytes of both AD and PD patients were 
      significantly higher than in controls. The majority of MN was composed of whole 
      chromosomes in AD patients, while a prevalence of MN arising from chromosome 
      breakage was observed in PD patients. Different molecular mechanisms underlie 
      cytogenetic alterations observed in peripheral lymphocytes of AD and PD patients.
FAU - Petrozzi, L
AU  - Petrozzi L
AD  - Department of Neuroscience, Clinical Neurology, Movement Disorders Unit, 
      University of Pisa, Via Roma 67, I-56126 Pisa, Italy.
FAU - Lucetti, C
AU  - Lucetti C
FAU - Scarpato, R
AU  - Scarpato R
FAU - Gambaccini, G
AU  - Gambaccini G
FAU - Trippi, F
AU  - Trippi F
FAU - Bernardini, S
AU  - Bernardini S
FAU - Del Dotto, P
AU  - Del Dotto P
FAU - Migliore, L
AU  - Migliore L
FAU - Bonuccelli, U
AU  - Bonuccelli U
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Neurol Sci
JT  - Neurological sciences : official journal of the Italian Neurological Society and 
      of the Italian Society of Clinical Neurophysiology
JID - 100959175
SB  - IM
MH  - Aged
MH  - Alzheimer Disease/*genetics/pathology
MH  - Case-Control Studies
MH  - *Chromosome Aberrations
MH  - Cytogenetic Analysis
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - *Lymphocytes/pathology
MH  - Male
MH  - Micronuclei, Chromosome-Defective/*genetics/pathology
MH  - Middle Aged
MH  - Parkinson Disease/*genetics/pathology
EDAT- 2003/01/28 04:00
MHDA- 2003/03/29 05:00
CRDT- 2003/01/28 04:00
PHST- 2003/01/28 04:00 [pubmed]
PHST- 2003/03/29 05:00 [medline]
PHST- 2003/01/28 04:00 [entrez]
AID - 10.1007/s100720200087 [doi]
PST - ppublish
SO  - Neurol Sci. 2002 Sep;23 Suppl 2:S97-8. doi: 10.1007/s100720200087.