PMID- 12549810
OWN - NLM
STAT- MEDLINE
DCOM- 20030212
LR  - 20041117
IS  - 0125-2208 (Print)
IS  - 0125-2208 (Linking)
VI  - 85 Suppl 4
DP  - 2002 Nov
TI  - Neonatal lupus erythematosus: clinical manifestations and management.
PG  - S1302-8
AB  - The authors report 6 cases of neonatal lupus erythematosus (NLE) who were seen at 
      Ramathibodi Hospital from 1993 to 2000. The female to male ratio was 1:5. 
      Cutaneous lesions were the major manifestation in all cases. Other clinical 
      manifestations were thrombocytopenia, hepatosplenomegaly and mild elevation of 
      liver enzymes. Skin rashes mostly erupted at 3-6 weeks old. None had a complete 
      heart block but one had abnormal electrocardiograph (ECG) changes compatible with 
      Wolff-Parkinson-White syndrome (WPW). Four of six patients had thrombocytopenia. 
      All of the abnormalities resolved spontaneously except thrombocytopenia. Three of 
      six needed blood transfusion to replace blood loss from gastrointestinal 
      bleeding. Intravenous immunoglobulin (IVIG) 2 g/kg was given in 3 cases with good 
      response in two of three cases. Platelets rose rapidly and maintained at a normal 
      level within 24-48 hours. Combined therapy with corticosteroid 2 mg/kg was given 
      to 1 case with good outcome. Telangiectasia was the most common sequelae 
      especially in patients who had periorbital lesions resembling raccoon's eyes. The 
      authors conclude that IVIG in the dose of 1 g/kg for 1-2 days is an effective 
      treatment for NLE with severe thrombocytopenia especially when corticosteroid is 
      contraindicated.
FAU - Chunharas, Amornsri
AU  - Chunharas A
AD  - Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol 
      University, Bangkok 10400, Thailand.
FAU - Nuntnarumit, Pracha
AU  - Nuntnarumit P
FAU - Hongeng, Suradej
AU  - Hongeng S
FAU - Chaunsumrit, Ampaiwan
AU  - Chaunsumrit A
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Thailand
TA  - J Med Assoc Thai
JT  - Journal of the Medical Association of Thailand = Chotmaihet thangphaet
JID - 7507216
SB  - IM
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - Lupus Erythematosus, Systemic/*diagnosis/*therapy
MH  - Male
EDAT- 2003/01/29 04:00
MHDA- 2003/02/14 04:00
CRDT- 2003/01/29 04:00
PHST- 2003/01/29 04:00 [pubmed]
PHST- 2003/02/14 04:00 [medline]
PHST- 2003/01/29 04:00 [entrez]
PST - ppublish
SO  - J Med Assoc Thai. 2002 Nov;85 Suppl 4:S1302-8.