PMID- 12549979
OWN - NLM
STAT- MEDLINE
DCOM- 20030423
LR  - 20181113
IS  - 0264-6021 (Print)
IS  - 1470-8728 (Electronic)
IS  - 0264-6021 (Linking)
VI  - 370
IP  - Pt 3
DP  - 2003 Mar 15
TI  - The identification and characterization of human Sister-of-Mammalian Grainyhead 
      (SOM) expands the grainyhead-like family of developmental transcription factors.
PG  - 953-62
AB  - The Drosophila gene grainyhead is the founding member of a large family of genes 
      encoding developmental transcription factors that are highly conserved from fly 
      to human. The family consists of two main branches, with grainyhead as the 
      ancestral gene for one branch and the recently cloned Drosophila CP2 as the 
      ancestral gene for the other. We now extend this family with the identification 
      of another novel mammalian member, Sister-of-Mammalian Grainyhead (SOM), which is 
      phylogenetically aligned with grainyhead. SOM is closely related to the other 
      mammalian homologues of grainyhead, including Mammalian Grainyhead (MGR) and 
      Brother-of-MGR, sharing a high degree of sequence identity with these factors in 
      the functional DNA-binding, protein dimerization and activation domains. Protein 
      interaction studies demonstrate that SOM can heterodimerize with MGR and 
      Brother-of-MGR, but not with the more distant members of the family. Like 
      grainyhead, the SOM gene too produces several distinct isoforms with differing 
      functional properties through alternative splicing. The tissue distributions of 
      these isoforms differ and all display highly restricted expression patterns. 
      These findings indicate that SOM, like its family members, may play important 
      roles in mammalian development.
FAU - Ting, Stephen B
AU  - Ting SB
AD  - Rotary Bone Marrow Research Laboratories, Royal Melbourne Hospital Research 
      Foundation, c/o Royal Melbourne Hospital Post Office, Grattan Street, Parkville, 
      Victoria 3050, Australia.
FAU - Wilanowski, Tomasz
AU  - Wilanowski T
FAU - Cerruti, Loretta
AU  - Cerruti L
FAU - Zhao, Lin-Lin
AU  - Zhao LL
FAU - Cunningham, John M
AU  - Cunningham JM
FAU - Jane, Stephen M
AU  - Jane SM
LA  - eng
GR  - P01 HL53749-06/HL/NHLBI NIH HHS/United States
GR  - P30 CA 21765/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Biochem J
JT  - The Biochemical journal
JID - 2984726R
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (GRHL2 protein, human)
RN  - 0 (GRHL3 protein, human)
RN  - 0 (Protein Isoforms)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Cloning, Molecular
MH  - DNA-Binding Proteins/chemistry/classification/genetics/*metabolism
MH  - Humans
MH  - Molecular Sequence Data
MH  - Phylogeny
MH  - Protein Isoforms/genetics/metabolism
MH  - Protein Structure, Tertiary
MH  - Sequence Alignment
MH  - Tissue Distribution
MH  - Transcription Factors/chemistry/classification/genetics/*metabolism
MH  - Two-Hybrid System Techniques
PMC - PMC1223248
EDAT- 2003/01/29 04:00
MHDA- 2003/04/24 05:00
PMCR- 2003/09/15
CRDT- 2003/01/29 04:00
PHST- 2002/12/09 00:00 [accepted]
PHST- 2002/11/19 00:00 [revised]
PHST- 2002/09/23 00:00 [received]
PHST- 2003/01/29 04:00 [pubmed]
PHST- 2003/04/24 05:00 [medline]
PHST- 2003/01/29 04:00 [entrez]
PHST- 2003/09/15 00:00 [pmc-release]
AID - BJ20021476 [pii]
AID - 10.1042/BJ20021476 [doi]
PST - ppublish
SO  - Biochem J. 2003 Mar 15;370(Pt 3):953-62. doi: 10.1042/BJ20021476.