PMID- 12550752
OWN - NLM
STAT- MEDLINE
DCOM- 20030303
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 140
IP  - 1
DP  - 2003 Jan 1
TI  - Different mechanisms lead to a karyotypically identical t(20;21) in 
      myelodysplastic syndrome and in acute myelocytic leukemia.
PG  - 13-7
AB  - A new t(20;21)(q11;q11), associated with a deletion on the long arm of chromosome 
      20, was found in one patient with an acute myelocytic leukemia (AML) and in one 
      with myelodysplastic syndrome (MDS). In both cases deletion was interstitial, 
      extending from band q11 to band q13, as shown by comparative genomic 
      hybridization (CGH) and fluorescence in situ hybridization (FISH). FISH analysis 
      with whole arm paints, subtelomeric probes, and locus-specific probes for the 
      long arms of chromosomes 20 and 21 revealed in patient 1 a reciprocal 
      translocation between the deleted 20q and the long arm of chromosome 21, that is, 
      del(20)(q11q13)t(20;21)(q11;q11), and in patient 2, material from 21q was 
      inserted into the deleted 20q, that is, del(20)(q11q13)ins(20;21)(q11;q11q22). 
      This is the first identification of a complex 20;21 rearrangement in MDS/AML. 
      Deletion at 20q and juxtaposition between 20q11 and 21q11 appear to be the 
      critical genomic events.
FAU - Matteucci, Caterina
AU  - Matteucci C
AD  - Ematologia, Universita degli Studi di Perugia, 06123, Perugia, Italy. 
      crimecux@unipg.it
FAU - La Starza, Roberta
AU  - La Starza R
FAU - Crescenzi, Barbara
AU  - Crescenzi B
FAU - Romoli, Silvia
AU  - Romoli S
FAU - Santoro, Alessandra
AU  - Santoro A
FAU - Magrin, Silvana
AU  - Magrin S
FAU - Lauria, Francesco
AU  - Lauria F
FAU - Coco, Francesco Lo
AU  - Coco FL
FAU - Martelli, Massimo F
AU  - Martelli MF
FAU - Mecucci, Cristina
AU  - Mecucci C
LA  - eng
PT  - Case Reports
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Aged
MH  - Anemia, Refractory, with Excess of Blasts/*genetics
MH  - Chromosome Banding
MH  - Chromosome Breakage
MH  - Chromosome Deletion
MH  - Chromosomes, Human, Pair 20/*genetics
MH  - Chromosomes, Human, Pair 21/*genetics
MH  - Fatal Outcome
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Leukemia, Myeloid, Acute/*genetics
MH  - Male
MH  - Middle Aged
MH  - Nucleic Acid Hybridization
MH  - *Translocation, Genetic
EDAT- 2003/01/29 04:00
MHDA- 2003/03/04 04:00
CRDT- 2003/01/29 04:00
PHST- 2003/01/29 04:00 [pubmed]
PHST- 2003/03/04 04:00 [medline]
PHST- 2003/01/29 04:00 [entrez]
AID - S0165460802006222 [pii]
AID - 10.1016/s0165-4608(02)00622-2 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2003 Jan 1;140(1):13-7. doi: 
      10.1016/s0165-4608(02)00622-2.