PMID- 12550762
OWN - NLM
STAT- MEDLINE
DCOM- 20030303
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 140
IP  - 1
DP  - 2003 Jan 1
TI  - Trisomy 8 as the sole chromosomal aberration in myelocytic malignancies: a 
      multicolor and locus-specific fluorescence in situ hybridization study.
PG  - 66-9
AB  - Trisomy 8 is the most common chromosomal aberration in myelocytic malignancies, 
      occurring both as a sole change as well as in addition to other abnormalities. In 
      spite of this, next to nothing is known about its pathogenetic importance or its 
      molecular genetic consequences. Possible mechanisms involved in the 
      transformation process include dosage effects of genes mapping to chromosome 8 
      and presence of specific mutations or cryptic fusion genes on the duplicated 
      chromosome. In the latter case, +8 would be secondary to a cryptic primary 
      rearrangement and not involved in leukemogenesis as such, but rather in tumor 
      evolution. Although hidden genetic changes have been found in some trisomies, for 
      example, mutations in KIT in acute myelocytic leukemia (AML) with +4 and in MET 
      in hereditary papillary kidney carcinoma with trisomy 7, none associated with +8 
      have so far been discovered. To address this issue, we have investigated a total 
      of 13 cases of AML, myelodysplastic syndromes, and chronic myeloproliferative 
      disorders with trisomy 8 as the sole chromosomal anomaly. All cases were studied 
      by combined binary ratio multicolor fluorescence in situ hybridization (FISH) and 
      with FISH using locus-specific probes for both arms of chromosome 8, the 
      subtelomeric regions of 8p and 8q, and the leukemia-associated genes FGFR1, MOZ, 
      ETO, and MYC. No cryptic changes were detected, thus excluding the possibility of 
      gross genetic rearrangements or aberrations involving these loci on chromosome 8.
FAU - Paulsson, Kajsa
AU  - Paulsson K
AD  - Department of Clinical Genetics, University Hospital, SE-221 85, Lund, Sweden. 
      kajsa.paulson@klingen.lu.se
FAU - Fioretos, Thoas
AU  - Fioretos T
FAU - Strombeck, Bodil
AU  - Strombeck B
FAU - Mauritzson, Nils
AU  - Mauritzson N
FAU - Tanke, Hans J
AU  - Tanke HJ
FAU - Johansson, Bertil
AU  - Johansson B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (DNA Probes)
SB  - IM
CIN - Cancer Genet Cytogenet. 2003 Oct 1;146(1):81-3. PMID: 14499702
MH  - Acute Disease
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anemia, Refractory/genetics
MH  - Anemia, Refractory, with Excess of Blasts/genetics
MH  - Chromosome Painting/*methods
MH  - *Chromosomes, Human, Pair 8
MH  - DNA Probes
MH  - Female
MH  - Humans
MH  - Leukemia, Myeloid/*genetics
MH  - Leukemia, Myelomonocytic, Chronic/genetics
MH  - Male
MH  - Middle Aged
MH  - Myelodysplastic Syndromes/*genetics
MH  - Myeloproliferative Disorders/*genetics
MH  - Oncogenes
MH  - *Trisomy
EDAT- 2003/01/29 04:00
MHDA- 2003/03/04 04:00
CRDT- 2003/01/29 04:00
PHST- 2003/01/29 04:00 [pubmed]
PHST- 2003/03/04 04:00 [medline]
PHST- 2003/01/29 04:00 [entrez]
AID - S0165460802006283 [pii]
AID - 10.1016/s0165-4608(02)00628-3 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2003 Jan 1;140(1):66-9. doi: 
      10.1016/s0165-4608(02)00628-3.