PMID- 12551983
OWN - NLM
STAT- MEDLINE
DCOM- 20030314
LR  - 20190508
IS  - 0022-538X (Print)
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Linking)
VI  - 77
IP  - 4
DP  - 2003 Feb
TI  - The human herpesvirus 6 U100 gene product is the third component of the gH-gL 
      glycoprotein complex on the viral envelope.
PG  - 2452-8
AB  - The human herpesvirus 6 (HHV-6) variant A U100 gene encodes the third component 
      of the glycoprotein H (gH)-glycoprotein L (gL)-containing complex. Glycosidase 
      digestion analysis showed that the U100 gene products are glycoproteins 
      consisting of an 80-kDa protein with complex N-linked oligosaccharides and a 
      74-kDa protein with immature, high-mannose N-linked oligosaccharides. Based on 
      these characteristics, we designated the U100 gene products glycoprotein Q (gQ). 
      Only the 80-kDa form of gQ was coimmunoprecipitated with an anti-gH antibody, 
      suggesting that the 80-kDa protein associates with the gH-gL complex in 
      HHV-6-infected cells. Furthermore, the complex was detected in purified virions, 
      suggesting that it may play an important role in viral entry.
FAU - Mori, Yasuko
AU  - Mori Y
AD  - Department of Microbiology, Osaka University Medical School, 2-2 Yamada-oka, 
      Suita, Osaka 565-0871, Japan. ymori@micro.med.osaka-u.ac.jp
FAU - Akkapaiboon, Pilailuk
AU  - Akkapaiboon P
FAU - Yang, Xuwei
AU  - Yang X
FAU - Yamanishi, Koichi
AU  - Yamanishi K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - 0 (UL115 protein, Human herpesvirus 5)
RN  - 0 (Viral Envelope Proteins)
RN  - 0 (Viral Proteins)
RN  - 0 (glycoprotein H, Cytomegalovirus)
RN  - 0 (glycoprotein H, Human cytomegalovirus)
SB  - IM
MH  - Cells, Cultured
MH  - Fetal Blood
MH  - Herpesvirus 6, Human/genetics/metabolism/*pathogenicity
MH  - Humans
MH  - Immunoblotting
MH  - Precipitin Tests
MH  - T-Lymphocytes/virology
MH  - Viral Envelope Proteins/genetics/*metabolism
MH  - Viral Proteins/*metabolism
PMC - PMC141122
EDAT- 2003/01/29 04:00
MHDA- 2003/03/15 04:00
PMCR- 2003/02/01
CRDT- 2003/01/29 04:00
PHST- 2003/01/29 04:00 [pubmed]
PHST- 2003/03/15 04:00 [medline]
PHST- 2003/01/29 04:00 [entrez]
PHST- 2003/02/01 00:00 [pmc-release]
AID - 1903 [pii]
AID - 10.1128/jvi.77.4.2452-2458.2003 [doi]
PST - ppublish
SO  - J Virol. 2003 Feb;77(4):2452-8. doi: 10.1128/jvi.77.4.2452-2458.2003.