PMID- 12554798
OWN - NLM
STAT- MEDLINE
DCOM- 20030220
LR  - 20191210
IS  - 0741-5400 (Print)
IS  - 0741-5400 (Linking)
VI  - 73
IP  - 2
DP  - 2003 Feb
TI  - Interleukin-18.
PG  - 213-24
AB  - Interleukin-18 (IL-18), a recently described member of the IL-1 cytokine 
      superfamily, is now recognized as an important regulator of innate and acquired 
      immune responses. IL-18 is expressed at sites of chronic inflammation, in 
      autoimmune diseases, in a variety of cancers, and in the context of numerous 
      infectious diseases. This short review will describe the basic biology of IL-18 
      and thereafter address its potential effector and regulatory role in several 
      human disease states including autoimmunity and infection. IL-18, previously 
      known as interferon-gamma (IFN-gamma)-inducing factor, was identified as an 
      endotoxin-induced serum factor that stimulated IFN-gamma production by murine 
      splenocytes [(1) ]. IL-18 was cloned from a murine liver cell cDNA library 
      generated from animals primed with heat-killed Propionibacterium acnes and 
      subsequently challenged with lipopolysaccharide [(2) ]. Nucleotide sequencing of 
      murine IL-18 predicted a precursor polypeptide of 192 amino acids lacking a 
      conventional signal peptide and a mature protein of 157 amino acids. Subsequent 
      cloning of human IL-18 cDNA revealed 65% homology with murine IL-18 [(3) ] and 
      showed that both contain an unusual leader sequence consisting of 35 amino acids 
      at their N terminus.
FAU - Gracie, J Alastair
AU  - Gracie JA
AD  - Centre for Rheumatic Diseases, University of Glasgow, 10 Alexandra Parade, 
      Glasgow G31 2ER, Scotland, UK.
FAU - Robertson, Susan E
AU  - Robertson SE
FAU - McInnes, Iain B
AU  - McInnes IB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - J Leukoc Biol
JT  - Journal of leukocyte biology
JID - 8405628
RN  - 0 (IL18R1 protein, human)
RN  - 0 (Interleukin-18)
RN  - 0 (Interleukin-18 Receptor alpha Subunit)
RN  - 0 (Receptors, Interleukin)
RN  - 0 (Receptors, Interleukin-18)
SB  - IM
MH  - Animals
MH  - Autoimmune Diseases/immunology
MH  - Gene Expression Regulation
MH  - Humans
MH  - Infections/immunology
MH  - Inflammation/immunology
MH  - Interleukin-18/antagonists & inhibitors/genetics/*physiology
MH  - Interleukin-18 Receptor alpha Subunit
MH  - Receptors, Interleukin/physiology
MH  - Receptors, Interleukin-18
RF  - 187
EDAT- 2003/01/30 04:00
MHDA- 2003/02/21 04:00
CRDT- 2003/01/30 04:00
PHST- 2003/01/30 04:00 [pubmed]
PHST- 2003/02/21 04:00 [medline]
PHST- 2003/01/30 04:00 [entrez]
AID - 10.1189/jlb.0602313 [doi]
PST - ppublish
SO  - J Leukoc Biol. 2003 Feb;73(2):213-24. doi: 10.1189/jlb.0602313.