PMID- 12558843
OWN - NLM
STAT- MEDLINE
DCOM- 20030612
LR  - 20190910
IS  - 0736-8046 (Print)
IS  - 0736-8046 (Linking)
VI  - 20
IP  - 1
DP  - 2003 Jan-Feb
TI  - Subacute cutaneous lupus erythematosus in childhood.
PG  - 31-4
AB  - We report a 7-year-old girl who presented with erythematous-infiltrated, 
      figurate, well-defined lesions over sun-exposed skin and antinuclear and Ro/SSA 
      antibodies. Lupus band test revealed granular IgM and microgranular C3 deposits 
      at the dermoepidermal junction. Histopathologic examination of lesional skin 
      showed orthohyperkeratosis, epidermal atrophy, widespread hydropic degeneration 
      of the epidermal basal cell layer, and a dermal perivascular lymphohistiocytic 
      infiltrate. The clinical, immunopathologic, and histopathologic findings were 
      consistent with the diagnosis of annular-polycyclic variant of subacute cutaneous 
      lupus erythematosus (SCLE). Treatment with hydroxychloroquine cleared the 
      cutaneous lesions. We report this patient because SCLE is extremely rare in 
      childhood, and discuss the two previous cases reported in the literature.
FAU - Amato, Lauretta
AU  - Amato L
AD  - Department of Dermatological Sciences, University of Florence, Florence, Italy.
FAU - Coronella, Giordana
AU  - Coronella G
FAU - Berti, Samantha
AU  - Berti S
FAU - Moretti, Silvia
AU  - Moretti S
FAU - Fabbri, Paolo
AU  - Fabbri P
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Pediatr Dermatol
JT  - Pediatric dermatology
JID - 8406799
RN  - 0 (Autoantibodies)
RN  - 4QWG6N8QKH (Hydroxychloroquine)
RN  - X4W7ZR7023 (Methylprednisolone)
SB  - IM
MH  - Acute Disease
MH  - Administration, Topical
MH  - Autoantibodies/analysis
MH  - Biopsy, Needle
MH  - Child
MH  - Drug Therapy, Combination
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Hydroxychloroquine/administration & dosage
MH  - Immunohistochemistry
MH  - Lupus Erythematosus, Cutaneous/diagnosis/drug therapy/*pathology
MH  - Methylprednisolone/administration & dosage
MH  - Severity of Illness Index
EDAT- 2003/02/01 04:00
MHDA- 2003/06/13 05:00
CRDT- 2003/02/01 04:00
PHST- 2003/02/01 04:00 [pubmed]
PHST- 2003/06/13 05:00 [medline]
PHST- 2003/02/01 04:00 [entrez]
AID - 3007 [pii]
AID - 10.1046/j.1525-1470.2003.03007.x [doi]
PST - ppublish
SO  - Pediatr Dermatol. 2003 Jan-Feb;20(1):31-4. doi: 10.1046/j.1525-1470.2003.03007.x.