PMID- 12559234
OWN - NLM
STAT- MEDLINE
DCOM- 20030320
LR  - 20190922
IS  - 1388-2457 (Print)
IS  - 1388-2457 (Linking)
VI  - 114
IP  - 2
DP  - 2003 Feb
TI  - Paired transcranial magnetic stimulation for the early diagnosis of corticobasal 
      degeneration.
PG  - 272-8
AB  - OBJECTIVE: To investigate cortical excitability in patients with corticobasal 
      degeneration (CBD) and to find a reliable diagnostic technique for 
      differentiating CBD from Parkinson's disease (PD). METHODS: Using a paired 
      transcranial magnetic stimulation technique, we studied motor cortex excitability 
      at rest in 6 patients with clinically probable CBD, 10 patients with PD, and 10 
      normal subjects. The recovery cycle of the motor evoked potentials was tested by 
      delivering paired magnetic stimulation over the hand area of the motor cortex at 
      interstimulus intervals (ISIs) from 1 to 17ms. RESULTS: In patients with CBD, 
      paired magnetic stimuli delivered at short ISIs invariably elicited enlarged test 
      MEPs. At ISIs of 1-10ms, the conditioned test MEPs were significantly larger in 
      patients with CBD than in control subjects; and at ISIs of 1, 2, 4, and 6ms,they 
      were also larger in patients with CBD than in patients with PD. At the other ISIs 
      tested, patients and control subjects had similar amplitude conditioned test 
      responses. CONCLUSIONS: Our findings suggest that the unusual clinical 
      manifestations of CBD might arise partly from motor cortex disinhibition. Paired 
      magnetic stimulation could be a useful diagnostic test particularly in the early 
      stages of the disease.
FAU - Frasson, E
AU  - Frasson E
AD  - Dipartimento di Scienze Neurologiche e della Visione, Sezione di Neurologia, 
      Verona, Italy.
FAU - Bertolasi, L
AU  - Bertolasi L
FAU - Bertasi, V
AU  - Bertasi V
FAU - Fusina, S
AU  - Fusina S
FAU - Bartolomei, L
AU  - Bartolomei L
FAU - Vicentini, S
AU  - Vicentini S
FAU - Rizzuto, N
AU  - Rizzuto N
FAU - Priori, A
AU  - Priori A
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Clin Neurophysiol
JT  - Clinical neurophysiology : official journal of the International Federation of 
      Clinical Neurophysiology
JID - 100883319
SB  - IM
MH  - Aged
MH  - Basal Ganglia/physiopathology
MH  - Cerebral Cortex/physiopathology
MH  - Diagnosis, Differential
MH  - Electric Stimulation
MH  - Evoked Potentials, Motor
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neurodegenerative Diseases/*diagnosis/physiopathology
MH  - Parkinson Disease/*diagnosis/physiopathology
MH  - *Transcranial Magnetic Stimulation
EDAT- 2003/02/01 04:00
MHDA- 2003/03/21 04:00
CRDT- 2003/02/01 04:00
PHST- 2003/02/01 04:00 [pubmed]
PHST- 2003/03/21 04:00 [medline]
PHST- 2003/02/01 04:00 [entrez]
AID - S1388245702003401 [pii]
AID - 10.1016/s1388-2457(02)00340-1 [doi]
PST - ppublish
SO  - Clin Neurophysiol. 2003 Feb;114(2):272-8. doi: 10.1016/s1388-2457(02)00340-1.