PMID- 12559653
OWN - NLM
STAT- MEDLINE
DCOM- 20030703
LR  - 20190815
IS  - 0006-3223 (Print)
IS  - 0006-3223 (Linking)
VI  - 53
IP  - 3
DP  - 2003 Feb 1
TI  - Activation of the medial prefrontal cortex and extended amygdala by individual 
      ratings of emotional arousal: a fMRI study.
PG  - 211-5
AB  - BACKGROUND: Significant differences between individual responses to emotional 
      stimuli can be important for the study of emotion. We investigated whether 
      incorporating individual ratings of emotional arousal in the analysis of 
      functional magnetic resonance imaging (fMRI) data improves the detection of 
      activation in the medial prefrontal cortex (MPFC) and sublenticular extended 
      amygdala (SLEA), areas implicated in the processing of emotional salience. 
      METHODS: Healthy subjects viewed counterbalanced blocks of aversive, nonaversive, 
      and blank images. Outside the scanner, they rated the intensity of emotional 
      arousal (salience) of each presented picture. RESULTS: Incorporating the 
      subject's response to each stimulus by using individualized regressors produced 
      more robust activations within MPFC and SLEA compared with a simple boxcar 
      regressor, identical for all subjects. CONCLUSIONS: Our findings demonstrate that 
      individual behavioral data are useful in improving detection of activation in 
      block-design functional imaging studies.
FAU - Phan, K Luan
AU  - Phan KL
AD  - Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109-0118, 
      USA.
FAU - Taylor, Stephan F
AU  - Taylor SF
FAU - Welsh, Robert C
AU  - Welsh RC
FAU - Decker, Laura R
AU  - Decker LR
FAU - Noll, Douglas C
AU  - Noll DC
FAU - Nichols, Thomas E
AU  - Nichols TE
FAU - Britton, Jennifer C
AU  - Britton JC
FAU - Liberzon, Israel
AU  - Liberzon I
LA  - eng
GR  - K08 MH01258/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Biol Psychiatry
JT  - Biological psychiatry
JID - 0213264
SB  - IM
MH  - Adult
MH  - Amygdala/physiology
MH  - Arousal/*physiology
MH  - Brain Mapping
MH  - Corpus Striatum/physiology
MH  - Emotions/*physiology
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Individuality
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Nerve Net/physiology
MH  - Prefrontal Cortex/*physiology
EDAT- 2003/02/01 04:00
MHDA- 2003/07/04 05:00
CRDT- 2003/02/01 04:00
PHST- 2003/02/01 04:00 [pubmed]
PHST- 2003/07/04 05:00 [medline]
PHST- 2003/02/01 04:00 [entrez]
AID - S0006322302014853 [pii]
AID - 10.1016/s0006-3223(02)01485-3 [doi]
PST - ppublish
SO  - Biol Psychiatry. 2003 Feb 1;53(3):211-5. doi: 10.1016/s0006-3223(02)01485-3.