PMID- 12560586
OWN - NLM
STAT- MEDLINE
DCOM- 20031008
LR  - 20190607
IS  - 1340-3478 (Print)
IS  - 1340-3478 (Linking)
VI  - 9
IP  - 6
DP  - 2002
TI  - Gene therapy targeting monocyte chemoattractant protein-1 for vascular disease.
PG  - 261-5
AB  - Monocyte chemoattractant protein-1 (MCP-1) has been shown to play an essential 
      role in the pathogenesis of arteriosclerosis and other vascular diseases, such as 
      restenosis after arterial injury, by recruiting monocytes into the arterial wall. 
      We devised a new strategy for anti-MCP-1 gene therapy against arteriosclerosis by 
      transfecting an amino-terminal deletion mutant (7ND), which lacks the 
      amino-terminal amino acids 2 to 8 of the human MCP-1 gene, into a remote organ 
      (skeletal muscles). Intramuscular transduction with the mutant MCP-1 gene 
      suppressed inflammatory and proliferative changes and arteriosclerosis formation 
      induced by the chronic inhibition of nitric oxide synthesis in rats. 7ND gene 
      transfection also inhibited the initiation, progression, and destabilization of 
      atherosclerosis in Apolipoprotein E-knockout mice. Moreover, the strategy reduced 
      restenosis after balloon injury in rabbits, rats, and monkeys, or neointimal 
      formation after stent implantation in monkeys. This new strategy may be a useful 
      and feasible gene therapy against atherosclerosis and restenosis after 
      angioplasty.
FAU - Kitamoto, Shiro
AU  - Kitamoto S
AD  - Department of Cardiovascular Medicine, Graduate School of Medical Sciences, 
      Kyushu University, Fukuoka, Japan.
FAU - Egashira, Kensuke
AU  - Egashira K
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - J Atheroscler Thromb
JT  - Journal of atherosclerosis and thrombosis
JID - 9506298
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Animals
MH  - Arteriosclerosis/immunology/*therapy
MH  - Chemokine CCL2/*genetics
MH  - Genetic Therapy/*methods
RF  - 19
EDAT- 2003/02/01 04:00
MHDA- 2003/10/09 05:00
CRDT- 2003/02/01 04:00
PHST- 2003/02/01 04:00 [pubmed]
PHST- 2003/10/09 05:00 [medline]
PHST- 2003/02/01 04:00 [entrez]
AID - 10.5551/jat.9.261 [doi]
PST - ppublish
SO  - J Atheroscler Thromb. 2002;9(6):261-5. doi: 10.5551/jat.9.261.