PMID- 12563613
OWN - NLM
STAT- MEDLINE
DCOM- 20031008
LR  - 20071115
IS  - 0037-1963 (Print)
IS  - 0037-1963 (Linking)
VI  - 40
IP  - 1
DP  - 2003 Jan
TI  - Autografting in chronic myeloid leukemia.
PG  - 72-8
AB  - Autografting (or autologous stem cell transplant [ASCT]) followed by "rescue" 
      with Philadelphia chromosome (Ph)-negative hematopoietic progenitor cells (HPC) 
      remains a good procedure to guarantee prolonged survival for patients mobilized 
      and autografted soon after diagnosis. Among 50 autografted patients who were 
      treated with interferon alpha (IFN-alpha) and imatinib (for cytogenetic relapse 
      after IFN-alpha), 41 are alive at a median of 51 months (range, 8 to 106 months). 
      Twenty-eight (56%) patients maintain major cytogenetic remission after ASCT + 
      IFN-alpha +/- imatinib. Such results are probably better than those achieved by 
      IFN-alpha alone and are similar to the best results obtained in younger patients 
      after allografting with human leukocyte antigen (HLA)-identical sibling donors. 
      The integration of imatinib, during the coming years, into an autografting 
      procedure could represent important progress towards developing a cure for 
      chronic myeloid leukemia (CML) patients who cannot undergo conventional 
      allografting.
CI  - Copyright 2003, Elsevier Science (USA). All rights reserved.
FAU - Carella, Angelo M
AU  - Carella AM
AD  - Department of Hematology/Oncology, IRCCS, Ospedale Casa Sollievo della 
      Sofferenza, San Giovanni Rotondo (FG), Italy.
FAU - Beltrami, Germana
AU  - Beltrami G
FAU - Corsetti, Maria T
AU  - Corsetti MT
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Semin Hematol
JT  - Seminars in hematology
JID - 0404514
RN  - 0 (Antineoplastic Agents)
SB  - IM
MH  - Antineoplastic Agents/therapeutic use
MH  - Antineoplastic Protocols
MH  - Hematopoietic Stem Cell Mobilization/methods
MH  - Humans
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*therapy
MH  - Peripheral Blood Stem Cell Transplantation/*methods
MH  - Remission Induction/methods
MH  - Transplantation, Autologous
RF  - 40
EDAT- 2003/02/04 04:00
MHDA- 2003/10/09 05:00
CRDT- 2003/02/04 04:00
PHST- 2003/02/04 04:00 [pubmed]
PHST- 2003/10/09 05:00 [medline]
PHST- 2003/02/04 04:00 [entrez]
AID - S0037196302000033 [pii]
AID - 10.1053/shem.2003.50001 [doi]
PST - ppublish
SO  - Semin Hematol. 2003 Jan;40(1):72-8. doi: 10.1053/shem.2003.50001.