PMID- 12563713
OWN - NLM
STAT- MEDLINE
DCOM- 20030801
LR  - 20171116
VI  - 14
IP  - 10
DP  - 2000 Oct
TI  - [Expression of CD44s and CD44v6 in laryngeal squamous cell carcinoma and their 
      significance].
PG  - 446-8
AB  - OBJECTIVE: To study the correlation between the expression of CD44s, CD44v6 and 
      the clinicopathological characters of laryngeal squamous cell carcinoma (LSCC) so 
      as to analyze the role of them in occurrence and progression of LSCC. METHOD: 
      Expression of CD44 and CD44v6 in 46 cases of LSCC and 20 cases of adjacent normal 
      tissues was inspected with immunohistochemical SP method. RESULT: The expression 
      of CD44s increased significantly in lymphnode metastasis group (94.4%) and stage 
      III-IV group (96.2%), but decreased in non-lymphnode metastasis group (67.9%) and 
      stage I-II group (55.0%). The expression of CD44v6 was lower (21.7%), which 
      wasn't associated with any clinicopathological characters. CONCLUSION: The role 
      of CD44 and CD44v6 in carcinoma maybe dependent on the species, type of 
      carcinoma, and the expression of CD44s may be a biologic marker to evaluate 
      metastasis of LSCC.
FAU - Wang, S L
AU  - Wang SL
AD  - Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of 
      Hubei Medical University, Wuhan 430060.
FAU - Yang, Q
AU  - Yang Q
FAU - Xiao, B K
AU  - Xiao BK
FAU - Jiang, Y S
AU  - Jiang YS
FAU - Chen, E H
AU  - Chen EH
LA  - chi
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Ke Za Zhi
JT  - Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
JID - 9426080
RN  - 0 (CD44v6 antigen)
RN  - 0 (Glycoproteins)
RN  - 0 (Hyaluronan Receptors)
SB  - IM
MH  - Aged
MH  - Carcinoma, Squamous Cell/*metabolism/secondary
MH  - Female
MH  - Glycoproteins/*biosynthesis
MH  - Humans
MH  - Hyaluronan Receptors/*biosynthesis
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
EDAT- 2003/02/05 04:00
MHDA- 2003/08/02 05:00
CRDT- 2003/02/05 04:00
PHST- 2003/02/05 04:00 [pubmed]
PHST- 2003/08/02 05:00 [medline]
PHST- 2003/02/05 04:00 [entrez]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2000 Oct;14(10):446-8.