PMID- 12563983
OWN - NLM
STAT- MEDLINE
DCOM- 20030610
LR  - 20140625
VI  - 13
IP  - 6
DP  - 1999 Jun
TI  - [Study on the correlation between the cyclin D1 and laryngeal squamous cell 
      carcinoma].
PG  - 268-70
AB  - OBJECTIVE: To study the correlation between the expression level of Cyclin D1 and 
      the laryngeal squamous cell carcinoma (LSCC). METHOD: 35 LSCC cases testified 
      pathologically were included in the study. The samples obtained from each tumor 
      tissue and adjacent normal mucosa were detected to see the expression level of 
      Cyclin D1 with the method of RT-PCR and light density half quantive analysis. 
      RESULT: The expression level of Cyclin D1 was significant higher in almost all 
      turmor tissues than in the adjacent normal mucosae (P < 0.05). Overexpressed 
      carcinomas were more frequently associated with lymph node metastases (P < 0.05). 
      A significant association between the expression level of Cyclin D1 and TNM was 
      found. The higher T stage, the higher the expression level of Cyclin D1 (P < 
      0.01). The expression level of low histological grade carcinomas was lower than 
      that of the high histological grade carcinomas, but the difference had no 
      statistical significance. No association between overexpression of Cyclin D1 and 
      sex, age was found too. CONCLUSION: The result indicates that the expression 
      level of Cyclin D1 in LSCC may be a useful marker of prognostic significance and 
      it provide a molecular biology basis for treating the LSCC patients.
FAU - Chen, J
AU  - Chen J
AD  - Department of ENT, Renji Hospital, Shanghai Medical University, Shanghai 200001.
FAU - Jin, X
AU  - Jin X
FAU - Zhou, L
AU  - Zhou L
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Ke Za Zhi
JT  - Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
JID - 9426080
RN  - 136601-57-5 (Cyclin D1)
SB  - IM
MH  - Aged
MH  - Carcinoma, Squamous Cell/*metabolism/pathology/secondary
MH  - Cyclin D1/*biosynthesis/genetics
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Reverse Transcriptase Polymerase Chain Reaction
EDAT- 2003/02/05 04:00
MHDA- 2003/06/11 05:00
CRDT- 2003/02/05 04:00
PHST- 2003/02/05 04:00 [pubmed]
PHST- 2003/06/11 05:00 [medline]
PHST- 2003/02/05 04:00 [entrez]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Ke Za Zhi. 1999 Jun;13(6):268-70.