PMID- 12569760
OWN - NLM
STAT- MEDLINE
DCOM- 20030527
LR  - 20111117
IS  - 1003-9279 (Print)
IS  - 1003-9279 (Linking)
VI  - 13
IP  - 3
DP  - 1999 Sep 30
TI  - [The study on clinical significance of human herpesvius 6 infection of NPC 
      tissues].
PG  - 262-5
AB  - OBJECTIVE: To study the infection of human herpesvirus 6(HHV-6) in NPC and its 
      role in the carcinogensis of NPC. METHODS: By using polymerase chain reaction 
      (PCR) and in situ hybridization (ISH) HHV-6 and EBV DNA to from the 
      paraffin-embedded tissues of normal nasopharynx precancerous nasopharynx and 
      nasopharyngeal carcinoma. EBV LMP1 was also detected in 36 tissues of NPC by 
      immunohistochemistry (IHC). RESULTS: HHV-6 DNA PCR were detected in 30.9% (13/42) 
      of tissues of NPC, 4.7% (1/21) of precancerous nasopharynx and non in the normal 
      nasopharynx. Within the same tissues, EBV DNA positive rates were 95.2% (40/42), 
      66.6% (14/21) and 25.9% (7/27), respectively. By using ISH, HHV-6 DNA were 
      detected only in 11 NPC tissues out of 13 HHV-6 DNA positive NPC cases and EBV 
      DNA were detected in 47.6% (10/21) of precancerous nasopharynx tissues and 85.7% 
      (36/42) of NPC cases. EBV LMP1 expression were detected in 47.2% (17/36) of NPC 
      tissues. CONCLUSION: NPC tissues can be infected with both HHV-6 and EBV, HHV-6 
      infection is correlated with the expression of EBV LMP1, suggesting that HHV-6 
      plays a direct/or indirect role in carcinogenesis of NPC via upregulating the 
      expression of EBV LMP1.
FAU - Chen, X
AU  - Chen X
AD  - Shenzhen Eastlake Hospital, Shenzhen, 518020.
FAU - Jian, S
AU  - Jian S
FAU - Wang, H
AU  - Wang H
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi
JT  - Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang 
      bingduxue zazhi = Chinese journal of experimental and clinical virology
JID - 9602873
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Carrier Proteins)
RN  - 0 (Cytoskeletal Proteins)
RN  - 0 (DNA, Viral)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (LIM Domain Proteins)
RN  - 0 (PDLIM7 protein, human)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing
MH  - Carrier Proteins/biosynthesis/genetics
MH  - Cytoskeletal Proteins
MH  - DNA, Viral/analysis
MH  - Herpesvirus 4, Human/isolation & purification
MH  - Herpesvirus 6, Human/*isolation & purification
MH  - Humans
MH  - Intracellular Signaling Peptides and Proteins
MH  - LIM Domain Proteins
MH  - Nasopharyngeal Neoplasms/*virology
MH  - Precancerous Conditions/*virology
MH  - *Roseolovirus Infections
EDAT- 2003/02/07 04:00
MHDA- 2003/05/28 05:00
CRDT- 2003/02/07 04:00
PHST- 2003/02/07 04:00 [pubmed]
PHST- 2003/05/28 05:00 [medline]
PHST- 2003/02/07 04:00 [entrez]
PST - ppublish
SO  - Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 1999 Sep 30;13(3):262-5.