PMID- 12570128
OWN - NLM
STAT- MEDLINE
DCOM- 20030516
LR  - 20190822
IS  - 0903-1936 (Print)
IS  - 0903-1936 (Linking)
VI  - 21
IP  - 1
DP  - 2003 Jan
TI  - Epoprostenol therapy for primary pulmonary hypertension after rejection of a 
      single donor lung.
PG  - 192-4
AB  - Before prostacyclins became available, lung or heart/lung transplantation was the 
      only effective treatment for patients with primary pulmonary hypertension (PPH) 
      who deteriorated under supportive medical treatment. Unfortunately, acute and 
      chronic rejections occur in a large number of cases, limiting the average 
      survival to 4.5 yrs. A female patient, age 35 yrs, was diagnosed with PPH and 
      underwent single lung transplantation. Despite aggressive immunosuppressive 
      therapy, the patient had several episodes of acute rejection. Eventually, chronic 
      rejection with bronchiolitis obliterans developed. After 5 yrs, the donor lung 
      was no longer functional. The patient was in New York Heart Association (NYHA) 
      class 4, had a 6-min walking distance of 50 m and a resting arterial oxygen 
      tension (Pa,O2) of 9.8 kPa (74 mmHg) when using 3 L x min(-1) of oxygen. 
      Epoprostenol treatment was started and the patient showed remarkable improvement. 
      After 17 months the patient was NYHA class 2, walked 503 m in 6 min and had a 
      resting Pa,O2 of 10.9 kPa (82 mmHg) without supplemental oxygen. In this patient, 
      treatment with epoprostenol was effective after rejection of a single donor lung 
      transplanted for primary pulmonary hypertension.
FAU - Roeleveld, R J
AU  - Roeleveld RJ
AD  - Dept of Pulmonology, VU University Medical Center, Amsterdam, The Netherlands. 
      rj.roeleveld@vumc.nl
FAU - Vonk Noordegraaf, A
AU  - Vonk Noordegraaf A
FAU - van der Bij, W
AU  - van der Bij W
FAU - Postmus, P E
AU  - Postmus PE
FAU - Boonstra, A
AU  - Boonstra A
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Eur Respir J
JT  - The European respiratory journal
JID - 8803460
RN  - 0 (Antihypertensive Agents)
RN  - DCR9Z582X0 (Epoprostenol)
SB  - IM
MH  - Adult
MH  - Antihypertensive Agents/*therapeutic use
MH  - Epoprostenol/*therapeutic use
MH  - Female
MH  - *Graft Rejection
MH  - Humans
MH  - Hypertension, Pulmonary/*drug therapy/surgery
MH  - *Lung Transplantation
EDAT- 2003/02/07 04:00
MHDA- 2003/05/17 05:00
CRDT- 2003/02/07 04:00
PHST- 2003/02/07 04:00 [pubmed]
PHST- 2003/05/17 05:00 [medline]
PHST- 2003/02/07 04:00 [entrez]
AID - 10.1183/09031936.03.00020902 [doi]
PST - ppublish
SO  - Eur Respir J. 2003 Jan;21(1):192-4. doi: 10.1183/09031936.03.00020902.