PMID- 12572877
OWN - NLM
STAT- MEDLINE
DCOM- 20030317
LR  - 20190922
IS  - 0944-1174 (Print)
IS  - 0944-1174 (Linking)
VI  - 37 Suppl 14
DP  - 2002 Nov
TI  - Polymorphisms of the IL-1beta and IL-1beta-inducible genes in ulcerative colitis.
PG  - 107-10
AB  - BACKGROUND: Ulcerative colitis (UC) is a chronic disorder of undetermined 
      etiology, but a genetic predisposition to UC is well recognized. Among cytokines 
      induced in UC, interleukin 1 (IL-1) appears to have a central role because of its 
      immunological upregulatory and proinflammatory activities. The aim of this study 
      was to assess whether UC is associated with polymorphisms of the IL-1beta gene 
      and three additional genes inducible with IL-1beta in Japanese subjects. METHODS: 
      A total of 96 patients with UC and 106 ethnically matched controls were genotyped 
      at polymorphic sites in IL-1beta, matrix metalloproteinase 1 (MMP-1), matrix 
      metalloproteinase 3 (MMP-3), and inducible nitric oxide synthase (iNOS) genes, 
      using polymerase chain reaction (PCR)-based methods. RESULTS: There was no 
      significant difference in genotype distributions of IL-1beta, MMP-1, MMP-3, and 
      iNOS genes between controls and UC patients in a Japanese population. Also, no 
      significant association of those polymorphisms with various clinical parameters 
      of the patients was found. However, concerning association of age at onset with 
      clinical factors in UC, the frequency of pancolitis was significantly higher in 
      UC patients with age at onset being less than 30 years than in those more than 30 
      years of age (P = 0.049). CONCLUSIONS: No association of the IL-1beta and three 
      IL-1beta-inducible gene polymorphisms with UC was observed in a Japanese 
      population.
FAU - Nohara, Hiroaki
AU  - Nohara H
AD  - Department of Gastroenterology and Hepatology, Yamaguchi University School of 
      Medicine, 1-1-1 Minami-kogushi, Ube 755-8505, Japan.
FAU - Saito, Yuki
AU  - Saito Y
FAU - Higaki, Singo
AU  - Higaki S
FAU - Okayama, Naoko
AU  - Okayama N
FAU - Hamanaka, Yuichiro
AU  - Hamanaka Y
FAU - Okita, Kiwamu
AU  - Okita K
FAU - Hinoda, Yuji
AU  - Hinoda Y
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Japan
TA  - J Gastroenterol
JT  - Journal of gastroenterology
JID - 9430794
RN  - 0 (Genetic Markers)
RN  - 0 (Interleukin-1)
RN  - 0 (Receptors, Interleukin-1)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
RN  - EC 3.4.24.7 (Matrix Metalloproteinase 1)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alleles
MH  - Base Sequence
MH  - Case-Control Studies
MH  - Colitis, Ulcerative/*genetics/physiopathology
MH  - Confidence Intervals
MH  - Female
MH  - Genetic Markers/genetics
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Interleukin-1/*genetics
MH  - Intestinal Mucosa/pathology
MH  - Japan
MH  - Male
MH  - Matrix Metalloproteinase 1/genetics
MH  - Matrix Metalloproteinase 3/genetics
MH  - Middle Aged
MH  - Molecular Sequence Data
MH  - Polymerase Chain Reaction/methods
MH  - *Polymorphism, Genetic
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Receptors, Interleukin-1/*genetics
MH  - Reference Values
MH  - Sensitivity and Specificity
MH  - Severity of Illness Index
EDAT- 2003/02/08 04:00
MHDA- 2003/03/18 04:00
CRDT- 2003/02/08 04:00
PHST- 2003/02/08 04:00 [pubmed]
PHST- 2003/03/18 04:00 [medline]
PHST- 2003/02/08 04:00 [entrez]
AID - 10.1007/BF03326427 [doi]
PST - ppublish
SO  - J Gastroenterol. 2002 Nov;37 Suppl 14:107-10. doi: 10.1007/BF03326427.