PMID- 12574791
OWN - NLM
STAT- MEDLINE
DCOM- 20030523
LR  - 20061115
IS  - 0950-9240 (Print)
IS  - 0950-9240 (Linking)
VI  - 17
IP  - 2
DP  - 2003 Feb
TI  - Subjects with essential hypertension are more sensitive to the inhibition of 11 
      beta-HSD by liquorice.
PG  - 125-31
AB  - In this intervention study, we have investigated if hypertensive patients are 
      more sensitive to liquorice-induced inhibition of 11 beta-hydroxysteroid 
      dehydrogenase (11 beta-HSD) type 2 than normotensive (NT) subjects and if the 
      response depends on gender. Healthy volunteers and patients with essential 
      hypertension (HT), consumed 100 g of liquorice daily, for 4 weeks, corresponding 
      to a daily intake of 150 mg glycyrrhetinic acid. Office, 24-h ambulatory blood 
      pressure (BP) and blood samples were measured before, during and after liquorice 
      consumption. Effect on cortisol metabolism was evaluated by determining the 
      urinary total cortisol metabolites and urinary free cortisol/free cortisone 
      quotient (Q). The mean rise in systolic BP with office measurements after 4 weeks 
      of liquorice consumption was 3.5 mmHg (p<0.06) in NT and 15.3 mmHg (p=0.003) in 
      hypertensive subjects, the response being different (p=0.004). The mean rise in 
      diastolic BP was 3.6 mmHg (p=0.01) in NT and 9.3 mmHg (p<0.001) in hypertensive 
      subjects, the response also being different (p=0.03). Liquorice induced more 
      pronounced clinical symptoms in women than in men (p=0.0008), although the 
      difference in the effect on the BP was not significant. The increase in Q was 
      prominent (p<0.0001) and correlated to the rise in BP (p=0.02). The rise in BP 
      was not dependant on age, the change in plasma renin activity or weight. We 
      conclude that patients with essential HT are more sensitive to the inhibition of 
      11 beta-HSD by liquorice than NT subjects, and that this inhibition causes more 
      clinical symptoms in women than in men.
FAU - Sigurjonsdottir, H A
AU  - Sigurjonsdottir HA
AD  - Department of Endocrinology, Grona Straket 8, Sahlgrenska University Hospital, 
      Sahlgrenska, 41345 Goteborg, Sweden. helga.sigurjonsdottir@medic.gu.se
FAU - Manhem, K
AU  - Manhem K
FAU - Axelson, M
AU  - Axelson M
FAU - Wallerstedt, S
AU  - Wallerstedt S
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Hum Hypertens
JT  - Journal of human hypertension
JID - 8811625
RN  - EC 1.1.- (Hydroxysteroid Dehydrogenases)
RN  - EC 1.1.1.146 (11-beta-Hydroxysteroid Dehydrogenases)
SB  - IM
MH  - 11-beta-Hydroxysteroid Dehydrogenases
MH  - Adult
MH  - Blood Pressure/drug effects/physiology
MH  - Body Mass Index
MH  - Female
MH  - Glycyrrhiza/*adverse effects
MH  - Humans
MH  - Hydroxysteroid Dehydrogenases/*antagonists & inhibitors/*drug effects
MH  - Hypersensitivity/*complications/*enzymology/physiopathology
MH  - Hypertension/*enzymology/*etiology/physiopathology
MH  - Male
MH  - Reference Values
MH  - Sex Factors
EDAT- 2003/02/08 04:00
MHDA- 2003/05/24 05:00
CRDT- 2003/02/08 04:00
PHST- 2003/02/08 04:00 [pubmed]
PHST- 2003/05/24 05:00 [medline]
PHST- 2003/02/08 04:00 [entrez]
AID - 1001504 [pii]
AID - 10.1038/sj.jhh.1001504 [doi]
PST - ppublish
SO  - J Hum Hypertens. 2003 Feb;17(2):125-31. doi: 10.1038/sj.jhh.1001504.