PMID- 12574905
OWN - NLM
STAT- MEDLINE
DCOM- 20050630
LR  - 20191106
IS  - 1203-4754 (Print)
IS  - 1203-4754 (Linking)
VI  - 7
IP  - 3
DP  - 2003 May-Jun
TI  - Subacute cutaneous lupus erythematosus induced by nifedipine.
PG  - 243-6
AB  - BACKGROUND: Subacute cutaneous lupus erythematosus (SCLE) has been reported to be 
      associated with the use of several drugs, including thiazides, terbinafine, and, 
      rarely, calcium channel blockers. OBJECTIVE: A case of SCLE induced by nifedipine 
      is presented. METHODS AND RESULTS: A 48-year-old white woman developed a 
      papulosquamous and annular eruption in sun-exposed areas during the summer. The 
      patient was taking nifedipine for essential hypertension for four years. Serology 
      showed the presence of antinuclear and anti-Ro/SSA as well as antihistone 
      antibodies. Histopathologic and immunopathologic (granular IgM deposits at the 
      dermoepidermal junction) findings confirmed the diagnosis of SCLE. Nifedipine 
      discontinuation led to rapid improvement with almost complete resolution of skin 
      lesions in one month in the absence of active treatment. Reduction of 
      antinuclear, anti-Ro/SSA, and antihistone antibody levels was documented after 
      six months. CONCLUSION: Nifedipine can cause SCLE after a long period of 
      administration. Antihistone antibodies may be associated with drug-induced SCLE.
FAU - Gubinelli, Emanuela
AU  - Gubinelli E
AD  - Istituto Dermopatico dell'Immacolata, IRCCS, Rome, Italy.
FAU - Cocuroccia, Barbara
AU  - Cocuroccia B
FAU - Girolomoni, Giampiero
AU  - Girolomoni G
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Cutan Med Surg
JT  - Journal of cutaneous medicine and surgery
JID - 9614685
RN  - 0 (Calcium Channel Blockers)
RN  - I9ZF7L6G2L (Nifedipine)
SB  - IM
MH  - Calcium Channel Blockers/*adverse effects
MH  - Female
MH  - Humans
MH  - Lupus Erythematosus, Cutaneous/*chemically induced
MH  - Middle Aged
MH  - Nifedipine/*adverse effects
EDAT- 2003/02/08 04:00
MHDA- 2005/07/01 09:00
CRDT- 2003/02/08 04:00
PHST- 2003/02/08 04:00 [pubmed]
PHST- 2005/07/01 09:00 [medline]
PHST- 2003/02/08 04:00 [entrez]
AID - 10.1007/s10227-002-0122-5 [doi]
PST - ppublish
SO  - J Cutan Med Surg. 2003 May-Jun;7(3):243-6. doi: 10.1007/s10227-002-0122-5.