PMID- 12575137
OWN - NLM
STAT- MEDLINE
DCOM- 20030923
LR  - 20131121
IS  - 1001-4454 (Print)
IS  - 1001-4454 (Linking)
VI  - 23
IP  - 3
DP  - 2000 Mar
TI  - [Study of xixin, duzhong and mixture to the antioxidant system of 
      D-galactose-induced senile mice].
PG  - 161-3
AB  - D-galactose induced mice aging model were used in this experiment. This study 
      investigated the effect of the herb on the activity of superoxide dismutase(SOD), 
      glutahione peroxidase (GSH-Px) and NOS, in order to know the damages degree of 
      body by free radical and determine the changes of above index after giving 
      Duzhong, Xixin and their Mixture 15, 30 and 45 days, at the same time, the 
      mechanism of their effect on antiaging was probed. The results were as follows: 
      The activity of SOD, GSH-Px and NOS was increasing before middel age and 
      decreasing after middelage(P < 0.01); Xixin and Duzhong could enhance the 
      activity of SOD, GSH-Px and NOS; The time of effect for mixture and Duzhong to 
      above index was short than Xixin's. The time of Mixture and Duzhong was 15 days, 
      and Xixin was 30 days.
FAU - Li, K
AU  - Li K
AD  - Jiamusi Medical College, Heilongjiang 154002.
FAU - Liu, M
AU  - Liu M
FAU - Wei, X
AU  - Wei X
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhong Yao Cai
JT  - Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
JID - 9426370
RN  - 0 (Drug Combinations)
RN  - 0 (Drugs, Chinese Herbal)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase Type I)
RN  - EC 1.14.13.39 (Nos1 protein, mouse)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - X2RN3Q8DNE (Galactose)
SB  - IM
MH  - Aging/*metabolism
MH  - Animals
MH  - Asarum/*chemistry
MH  - Brain/metabolism
MH  - Drug Combinations
MH  - Drugs, Chinese Herbal/isolation & purification/*pharmacology
MH  - Eucommiaceae/*chemistry
MH  - Female
MH  - Galactose
MH  - Glutathione Peroxidase/metabolism
MH  - Male
MH  - Mice
MH  - Nitric Oxide Synthase/metabolism
MH  - Nitric Oxide Synthase Type I
MH  - Plants, Medicinal/chemistry
MH  - Superoxide Dismutase/metabolism
EDAT- 2003/02/11 04:00
MHDA- 2003/09/25 05:00
CRDT- 2003/02/11 04:00
PHST- 2003/02/11 04:00 [pubmed]
PHST- 2003/09/25 05:00 [medline]
PHST- 2003/02/11 04:00 [entrez]
PST - ppublish
SO  - Zhong Yao Cai. 2000 Mar;23(3):161-3.