PMID- 12575374
OWN - NLM
STAT- MEDLINE
DCOM- 20030430
LR  - 20161018
IS  - 1003-5370 (Print)
IS  - 1003-5370 (Linking)
VI  - 21
IP  - 11
DP  - 2001 Nov
TI  - [Effect of new zhengtian pill on expression of whole blood platelet membrane 
      adhesion molecules in patients of migraine].
PG  - 822-4
AB  - OBJECTIVE: To investigate the effect of New Zhengtian Pill (NZTP) on expression 
      of whole blood platelet membrane adhesion molecules (PMAM) in patients of 
      migraine. METHODS: Sixty-eight patients were divided into two groups, the 35 
      patients in the treated group treated by NZTP orally and the 33 patients in the 
      control group treated by Fuguiqin Capsule with a therapeutic course of 30 days 
      for both groups. Changes of PMAM GP II b/III a(CD41) and P-selectin (CD62P) were 
      observed by flow-cytometry and compared with those in healthy persons. RESULTS: 
      The markedly effective rate and total effective rate in the treated group was 
      higher than those in the control group respectively (P < 0.05 and P < 0.01). The 
      PMAM expression was also higher in patients, both at onset stage and intermittent 
      stage, than in healthy persons (P < 0.01), NZTP treatment could reduce their 
      increased expression significantly (P < 0.01). CONCLUSION: NZTP could reduce the 
      PMAM expression and inhibit the activation of platelet.
FAU - Zhu, C Q
AU  - Zhu CQ
AD  - Department of TCM, Nanfang Hospital, First Military Medical University, Guangzhou 
      510515.
FAU - Xie, W
AU  - Xie W
FAU - Chan, B T
AU  - Chan BT
LA  - chi
PT  - Clinical Trial
PT  - English Abstract
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Zhong Xi Yi Jie He Za Zhi
JT  - Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese 
      journal of integrated traditional and Western medicine
JID - 9211576
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (P-Selectin)
RN  - 0 (Platelet Glycoprotein GPIIb-IIIa Complex)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Drugs, Chinese Herbal/*therapeutic use
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Migraine Disorders/*drug therapy/*metabolism
MH  - P-Selectin/blood
MH  - *Phytotherapy
MH  - Platelet Activation
MH  - Platelet Glycoprotein GPIIb-IIIa Complex/*biosynthesis
EDAT- 2003/02/11 04:00
MHDA- 2003/05/06 05:00
CRDT- 2003/02/11 04:00
PHST- 2003/02/11 04:00 [pubmed]
PHST- 2003/05/06 05:00 [medline]
PHST- 2003/02/11 04:00 [entrez]
PST - ppublish
SO  - Zhongguo Zhong Xi Yi Jie He Za Zhi. 2001 Nov;21(11):822-4.