PMID- 12575607
OWN - NLM
STAT- MEDLINE
DCOM- 20030429
LR  - 20211203
IS  - 1003-5370 (Print)
IS  - 1003-5370 (Linking)
VI  - 21
IP  - 10
DP  - 2001 Oct
TI  - [Study on effect of Astragalus injection in treating congestive heart failure].
PG  - 747-9
AB  - OBJECTIVE: To observe the clinical efficacy and side-effects of Astragalus 
      Injection (AI) in treating congestive heart failure (CHF). METHODS: Eighty-three 
      patients of CHF with heart function of II-IV grade assessed by NYHA (New York 
      Heart Association) classification were randomly divided into 2 groups. The 42 
      patients in the treated group were treated with AI 40 ml (equivalent to 80 g 
      crude drug) by adding in 5% glucose solution 500 ml for intravenous dripping, 
      once a day and the 41 patients in the control group were treated by nitrolingual 
      injection 15 mg by adding in 5% glucose solution 500 ml for intravenous dripping 
      once a day. The therapeutic course in both groups was 2 weeks and the patients 
      were followed-up for 1-6 months. RESULTS: The clinical heart function improvement 
      rate and the total effective rate in the treated group after 1 month treatment 
      were 26.2% and 78.6%, and after 6 months were 34.2% and 81.6% respectively, which 
      were superior to those in the control group significantly (P < 0.05 or P < 0.01). 
      The levels of left ventricular ejection fraction (LVEF), fractional shortening of 
      left ventricular short axis (FS), the ratio of maximum blood flow between the 
      advanced and early atrial systole (E/A), stroke volume (SV), cardiac output (CO) 
      and the cardiac index (CI) were all improved in both groups (P < 0.01 or P < 
      0.05), but better improvement was shown in the treated group. Follow-up study 
      showed that the incidence of cardiac event was lower in the treated group than 
      that in the control group (P < 0.05). CONCLUSION: AI can be took as one of the 
      important auxiliary drugs for treatment of CHF especially in severe cases.
FAU - Zhou, Z L
AU  - Zhou ZL
AD  - Third People's Hospital, Hangzhou 310009.
FAU - Yu, P
AU  - Yu P
FAU - Lin, D
AU  - Lin D
LA  - chi
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - China
TA  - Zhongguo Zhong Xi Yi Jie He Za Zhi
JT  - Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese 
      journal of integrated traditional and Western medicine
JID - 9211576
RN  - 0 (Digitalis Glycosides)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 922OP8YUPF (Huang Qi)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Astragalus Plant/adverse effects
MH  - Astragalus propinquus
MH  - Cardiac Output/drug effects
MH  - Digitalis Glycosides/*therapeutic use
MH  - Drug Therapy, Combination
MH  - Drugs, Chinese Herbal/adverse effects/*therapeutic use
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/*drug therapy
MH  - Humans
MH  - Injections, Intravenous
MH  - Male
MH  - Middle Aged
MH  - *Phytotherapy
MH  - Stroke Volume/drug effects
EDAT- 2003/02/11 04:00
MHDA- 2003/04/30 05:00
CRDT- 2003/02/11 04:00
PHST- 2003/02/11 04:00 [pubmed]
PHST- 2003/04/30 05:00 [medline]
PHST- 2003/02/11 04:00 [entrez]
PST - ppublish
SO  - Zhongguo Zhong Xi Yi Jie He Za Zhi. 2001 Oct;21(10):747-9.