PMID- 12575925
OWN - NLM
STAT- Publisher
LR  - 20191120
IS  - 2058-7384 (Electronic)
IS  - 0394-6320 (Linking)
VI  - 15
IP  - 3
DP  - 2002 Sep-Dec
TI  - Evidence for a T-lymphocyte dependent mechanism involving proinflammatory 
      cytokines in anticonvulsant hypersensitivity syndrome: a case report.
PG  - 239-242
AB  - The anticonvulsant drug hypersensitivity syndrome (AHS) is a potentially fatal 
      drug reaction associated with aromatic antiepileptic drugs, the pathogenic 
      mechanisms of which are still unclear. We studied a 2-year-old female affected 
      with AHS after phenobarbital treatment. In vitro experiments showed a 
      T-lymphocyte response to the drug and an increased, dose-related, IL-6 production 
      after drug incubation. These findings suggest that AHS may be caused by a 
      T-lymphocyte dependent mechanism, involving pro-inflammatory cytokines.
FAU - Chiappini, E
AU  - Chiappini E
AD  - Div. Pediatrics, University of Florence, Italy.
FAU - Peruzzi, M
AU  - Peruzzi M
FAU - Galli, L
AU  - Galli L
FAU - Calabri, G
AU  - Calabri G
FAU - De Martino, M
AU  - De Martino M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int J Immunopathol Pharmacol
JT  - International journal of immunopathology and pharmacology
JID - 8911335
EDAT- 2003/02/11 04:00
MHDA- 2003/02/11 04:00
CRDT- 2003/02/11 04:00
PHST- 2003/02/11 04:00 [pubmed]
PHST- 2003/02/11 04:00 [medline]
PHST- 2003/02/11 04:00 [entrez]
AID - 11 [pii]
AID - 10.1177/039463200201500311 [doi]
PST - ppublish
SO  - Int J Immunopathol Pharmacol. 2002 Sep-Dec;15(3):239-242. doi: 
      10.1177/039463200201500311.