PMID- 12576115
OWN - NLM
STAT- MEDLINE
DCOM- 20030520
LR  - 20190712
IS  - 0031-9384 (Print)
IS  - 0031-9384 (Linking)
VI  - 78
IP  - 2
DP  - 2003 Feb
TI  - Effects of alcohol exposure during development on social behavior in rats.
PG  - 185-94
AB  - In addition to the cognitive deficits associated with fetal alcohol syndrome 
      (FAS), clinical and animal studies indicate that alcohol exposure might also have 
      detrimental effects on social behavior. In a rat model of FAS, experimental rats 
      were given alcohol from gestational day (GD) 1 to 22 and from postnatal day (PD) 
      2 to 10, a period roughly equivalent to all three trimesters in humans. Control 
      groups consisted of rats exposed to the administration procedures but not to 
      alcohol and nontreated rats. At 30 days of age, rats were tested for social 
      behavior in an alley maze that contained its cagemate in the goal box. After 
      varying periods of isolation, the animals' latencies to reach the goal box and 
      their social behaviors once inside the goal box were recorded. Alcohol-exposed 
      animals ran faster than control rats to the occupied goal box regardless of the 
      amount of isolation. The alcohol-exposed animals also exhibited aberrant social 
      interactions with their cagemate once inside the goal box compared to one or both 
      of the control groups. Specifically, the alcohol-exposed animals showed greater 
      amounts of anogenital sniffing, chasing, hopping and darting, and retrieving and 
      lesser amounts of pinning and biting compared to one or both of the control 
      groups. The alcohol-induced change in anogenital sniffing varied over increasing 
      amounts of isolation compared to both control groups, but the alterations in the 
      other behaviors did not. It is argued that the altered social behavior of 
      alcohol-exposed animals is not the result of changes in the animals' motivational 
      state or social learning and may be the result of an increased responsiveness to 
      social stimuli.
FAU - Lugo, J N Jr
AU  - Lugo JN Jr
AD  - Department of Psychology, University of South Carolina, Columbia, SC 29208, USA.
FAU - Marino, M D
AU  - Marino MD
FAU - Cronise, K
AU  - Cronise K
FAU - Kelly, S J
AU  - Kelly SJ
LA  - eng
GR  - F31 AA005583/AA/NIAAA NIH HHS/United States
GR  - AA05583/AA/NIAAA NIH HHS/United States
GR  - AA11566/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Physiol Behav
JT  - Physiology & behavior
JID - 0151504
RN  - 0 (Central Nervous System Depressants)
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Animals, Newborn/*psychology
MH  - Behavior, Animal/*drug effects
MH  - Central Nervous System Depressants/*administration & dosage
MH  - Ethanol/*administration & dosage
MH  - Female
MH  - Fetus/*drug effects
MH  - Male
MH  - Maze Learning/drug effects
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Rats
MH  - *Social Behavior
EDAT- 2003/02/11 04:00
MHDA- 2003/05/21 05:00
CRDT- 2003/02/11 04:00
PHST- 2003/02/11 04:00 [pubmed]
PHST- 2003/05/21 05:00 [medline]
PHST- 2003/02/11 04:00 [entrez]
AID - S003193840200971X [pii]
AID - 10.1016/s0031-9384(02)00971-x [doi]
PST - ppublish
SO  - Physiol Behav. 2003 Feb;78(2):185-94. doi: 10.1016/s0031-9384(02)00971-x.