PMID- 12576204
OWN - NLM
STAT- MEDLINE
DCOM- 20030424
LR  - 20220410
IS  - 0378-8741 (Print)
IS  - 0378-8741 (Linking)
VI  - 85
IP  - 1
DP  - 2003 Mar
TI  - Anti-oxidant activities of the extracts from the herbs of Artemisia apiacea.
PG  - 69-72
AB  - The anti-oxidant activities of the various fractions from the herbs of Artemisia 
      apiacea were investigated. The n-hexane and n-butanol fractions were found to 
      cause significant free radical scavenging effects on DPPH, their scavenging 
      potencies as indicated in IC(50) values, being 230.1 and 183.7 microg/ml, 
      respectively. The n-butanol fraction exhibited a significant decrease in serum 
      transaminase activities elevated by hepatic damage induced by CCl(4)-intoxication 
      in rats. All fractions tested exhibited a lipid peroxidation causing a 
      significant decrease in MDA production in TBA-reactant assay. The n-butanol 
      fraction was the strongest in the increase in the anti-oxidant enzymes such as 
      hepatic cytosolic superoxide dismutase (SOD), catalase and glutathione peroxidase 
      (GSH-px) activities in CCl(4)-intoxicated rats. These results suggest that the 
      herbs of A. apiacea possess not only the anti-oxidant, but also the activities in 
      CCl(4)-intoxicated rats. Especially, the n-butanol extract was found to cause 
      significant increases in the rat liver cytosolic SOD, catalase, GSH-px activities 
      as well as a significant decrease in the MDA production.
FAU - Kim, Kyoung Soon
AU  - Kim KS
AD  - College of Pharmacy, Seoul National University, San 56-1, Shillim-Dong, 
      Gwanak-Gu, South Korea.
FAU - Lee, Sanghyun
AU  - Lee S
FAU - Lee, Yeon Sil
AU  - Lee YS
FAU - Jung, Sang Hoon
AU  - Jung SH
FAU - Park, Youmie
AU  - Park Y
FAU - Shin, Kuk Hyun
AU  - Shin KH
FAU - Kim, Bak-Kwang
AU  - Kim BK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - J Ethnopharmacol
JT  - Journal of ethnopharmacology
JID - 7903310
RN  - 0 (Antioxidants)
RN  - 0 (Biphenyl Compounds)
RN  - 0 (Free Radical Scavengers)
RN  - 0 (Picrates)
RN  - 0 (Plant Extracts)
RN  - 0 (Solvents)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl)
RN  - EC 2.6.1.1 (Aspartate Aminotransferases)
RN  - EC 2.6.1.2 (Alanine Transaminase)
SB  - IM
MH  - Alanine Transaminase/blood
MH  - Animals
MH  - Antioxidants/chemistry/*pharmacology/therapeutic use
MH  - *Artemisia
MH  - Aspartate Aminotransferases/blood
MH  - Biphenyl Compounds
MH  - Carbon Tetrachloride Poisoning/drug therapy/metabolism
MH  - Free Radical Scavengers/chemistry
MH  - In Vitro Techniques
MH  - Lipid Peroxidation/drug effects
MH  - Liver/drug effects/metabolism/ultrastructure
MH  - Male
MH  - Malondialdehyde/metabolism
MH  - Phytotherapy
MH  - Picrates/chemistry
MH  - Plant Extracts/chemistry/pharmacology/therapeutic use
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Solvents
EDAT- 2003/02/11 04:00
MHDA- 2003/04/25 05:00
CRDT- 2003/02/11 04:00
PHST- 2003/02/11 04:00 [pubmed]
PHST- 2003/04/25 05:00 [medline]
PHST- 2003/02/11 04:00 [entrez]
AID - S0378874102003380 [pii]
AID - 10.1016/s0378-8741(02)00338-0 [doi]
PST - ppublish
SO  - J Ethnopharmacol. 2003 Mar;85(1):69-72. doi: 10.1016/s0378-8741(02)00338-0.