PMID- 12579504
OWN - NLM
STAT- MEDLINE
DCOM- 20030902
LR  - 20061115
IS  - 1003-9406 (Print)
IS  - 1003-9406 (Linking)
VI  - 20
IP  - 1
DP  - 2003 Feb
TI  - [Detection of chromosome 8 anomalies in ovarian carcinoma by fluorescence in situ 
      hybridization].
PG  - 59-60
AB  - OBJECTIVE: To detect the relationship between chromosomal anomalies and the 
      pathogenesis, development and prognosis of ovarian carcinoma. METHODS: Thirty-six 
      specimens of ovarian carcinoma (n=12), ovarian benign tumor (n=12), and normal 
      ovary (n=12) were examined by fluorescence in situ hybridization (FISH). RESULTS: 
      Twelve cases of mutations, including trisomy 8, monosomy 8 or tetraploid 8 
      chromosomal anomalies, were found in the group of ovarian carcinoma, making up 
      100% (12/12). Three cases of trisomy 8 chromosomal anomalies were found in the 
      group of ovarian benign tumor, accounting for 25% (3/12). No anomaly was found in 
      the normal group. There were significant differences between the three groups, 
      P<0.001. CONCLUSION: The above anomalies of chromosome 8 are significantly 
      associated with the pathogenesis and development of ovarian carcinoma. The 
      anomalies may occur in the early stage of the carcinoma, and may be significantly 
      associated with the pathological differentiation and clinical stage of the case.
FAU - Dong, Yue-lan
AU  - Dong YL
AD  - Department of Gynecology, the First People's Hospital of Yunnan Province, 
      Kunming, PR China.
FAU - Li, Chun-hua
AU  - Li CH
FAU - Chen, Li-xin
AU  - Chen LX
FAU - Feng, Huai-ying
AU  - Feng HY
FAU - Zhu, Bao-sheng
AU  - Zhu BS
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi
JT  - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese 
      journal of medical genetics
JID - 9425197
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aneuploidy
MH  - *Chromosome Aberrations
MH  - Chromosomes, Human, Pair 8/*genetics
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/methods
MH  - Middle Aged
MH  - Monosomy
MH  - Ovarian Neoplasms/*genetics
MH  - Trisomy
EDAT- 2003/02/13 04:00
MHDA- 2003/09/03 05:00
CRDT- 2003/02/13 04:00
PHST- 2003/02/13 04:00 [pubmed]
PHST- 2003/09/03 05:00 [medline]
PHST- 2003/02/13 04:00 [entrez]
PST - ppublish
SO  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2003 Feb;20(1):59-60.