PMID- 12579992
OWN - NLM
STAT- MEDLINE
DCOM- 20030226
LR  - 20230601
IS  - 0002-9173 (Print)
IS  - 0002-9173 (Linking)
VI  - 119
IP  - 2
DP  - 2003 Feb
TI  - B-cell lymphomas with coexpression of CD5 and CD10.
PG  - 218-30
AB  - Coexpression of CD5 and CD10 is highly unusual in B-cell lymphomas and may pose a 
      diagnostic challenge. We report 42 cases of B-cell lymphoma with simultaneous 
      expression of CD5 and CD10. They made up approximately 0.4% of all B-cell 
      lymphomas seen during the study period and included the following cases: large 
      B-cell lymphoma (LBCL), 14 (33%); follicular lymphoma (FL), 10 (24%); mantle cell 
      lymphoma (MCL), 9 (21%); chronic lymphocytic leukemia, 4 (10%); acute precursor 
      B-cell lymphoblastic leukemia/lymphoma, 2 (5%); and other low-grade B-cell 
      lymphomas, 3 (7%). All MCLs had overexpression of bcl-1 or the t(11;14) and were 
      CD43+. All FLs had typical histomorphologic features and were bcl-2+ and bcl-6+ 
      but CD43-. Of 14 LBCLs, 5 were histologically high-grade. Six (43%) of 14 
      patients with LBCL died within 10 months of diagnosis of CD5+CD10+ lymphoma 
      (median survival, 4 months), including all 3 patients with stage IV disease and 2 
      of 5 with histologically high-grade lymphoma. Our findings indicate that 
      coexpression of CD5 and CD10 is rare but occurs in diverse subtypes of B-cell 
      lymphoma. Investigation of bcl-1, bcl-6, and CD43 and morphologic evaluation may 
      resolve the potential confusion in diagnosis and lead to the recognition of the 
      correct lymphoma subtype.
FAU - Dong, Henry Y
AU  - Dong HY
AD  - IMPATH Inc, 521W 57th St, 6th Floor, New York, NY 10019, USA.
FAU - Gorczyca, Wojciech
AU  - Gorczyca W
FAU - Liu, Zach
AU  - Liu Z
FAU - Tsang, Patricia
AU  - Tsang P
FAU - Wu, C Daniel
AU  - Wu CD
FAU - Cohen, Patti
AU  - Cohen P
FAU - Weisberger, James
AU  - Weisberger J
LA  - eng
PT  - Journal Article
PL  - England
TA  - Am J Clin Pathol
JT  - American journal of clinical pathology
JID - 0370470
RN  - 0 (Antigens, CD)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (CD5 Antigens)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Leukosialin)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Proto-Oncogene Proteins c-bcl-6)
RN  - 0 (SPN protein, human)
RN  - 0 (Sialoglycoproteins)
RN  - 0 (Transcription Factors)
RN  - 136601-57-5 (Cyclin D1)
RN  - EC 3.4.24.11 (Neprilysin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Antigens, CD
MH  - Biomarkers, Tumor/metabolism
MH  - CD5 Antigens/*metabolism
MH  - Cyclin D1/metabolism
MH  - DNA-Binding Proteins/metabolism
MH  - Female
MH  - Flow Cytometry
MH  - Fluorescent Antibody Technique, Indirect
MH  - Humans
MH  - Immunohistochemistry
MH  - Immunophenotyping
MH  - In Situ Hybridization, Fluorescence
MH  - Leukosialin
MH  - Lymphoma, B-Cell/classification/*metabolism/pathology
MH  - Male
MH  - Middle Aged
MH  - Neprilysin/*metabolism
MH  - Proto-Oncogene Proteins/metabolism
MH  - Proto-Oncogene Proteins c-bcl-6
MH  - Sialoglycoproteins/metabolism
MH  - Transcription Factors/metabolism
EDAT- 2003/02/13 04:00
MHDA- 2003/02/27 04:00
CRDT- 2003/02/13 04:00
PHST- 2003/02/13 04:00 [pubmed]
PHST- 2003/02/27 04:00 [medline]
PHST- 2003/02/13 04:00 [entrez]
AID - 10.1309/u98advkuc26r2rja [doi]
PST - ppublish
SO  - Am J Clin Pathol. 2003 Feb;119(2):218-30. doi: 10.1309/u98advkuc26r2rja.