PMID- 12580542
OWN - NLM
STAT- MEDLINE
DCOM- 20030331
LR  - 20240426
IS  - 1015-6305 (Print)
IS  - 1750-3639 (Electronic)
IS  - 1015-6305 (Linking)
VI  - 13
IP  - 1
DP  - 2003 Jan
TI  - Inflammation in the central nervous system: the role for dendritic cells.
PG  - 23-33
AB  - Dendritic cells (DCs) are a subclass of antigen-presenting cells critical in the 
      initiation and regulation of adaptive immunity against pathogens and tumors, as 
      well as in the triggering of autoimmunity. Recent studies have provided important 
      knowledge regarding distribution of DCs in the central nervous system (CNS) and 
      their role in intrathecal immune responses. DCs are present in normal meninges, 
      choroid plexus, and cerebrospinal fluid, but absent from the normal brain 
      parenchyma. Inflammation is accompanied by recruitment and/or development of DCs 
      in the affected brain tissue. DCs present in different compartments of the CNS 
      are likely to play a role in the defence against CNS infections, and also may 
      contribute to relapses/chronicity of CNS inflammation and to break-down of 
      tolerance to CNS autoantigens. CNS DCs can therefore be viewed as a future 
      therapeutic target in chronic inflammatory diseases such as multiple sclerosis.
FAU - Pashenkov, Mikhail
AU  - Pashenkov M
AD  - Neuroimmunology Unit, Division of Neurology, Karolinska Institutet, Huddinge 
      University Hospital, Stockholm, Sweden. Mikhail.Pashenkov@neurotec.ki.se
FAU - Teleshova, Natalia
AU  - Teleshova N
FAU - Link, Hans
AU  - Link H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Switzerland
TA  - Brain Pathol
JT  - Brain pathology (Zurich, Switzerland)
JID - 9216781
SB  - IM
MH  - Animals
MH  - Central Nervous System/*cytology/*immunology
MH  - Central Nervous System Diseases/immunology
MH  - Cerebrospinal Fluid/cytology/*immunology
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Immunity, Cellular
MH  - Inflammation/*immunology
PMC - PMC8095979
EDAT- 2003/02/13 04:00
MHDA- 2003/04/01 05:00
PMCR- 2006/04/05
CRDT- 2003/02/13 04:00
PHST- 2003/02/13 04:00 [pubmed]
PHST- 2003/04/01 05:00 [medline]
PHST- 2003/02/13 04:00 [entrez]
PHST- 2006/04/05 00:00 [pmc-release]
AID - BPA23 [pii]
AID - 10.1111/j.1750-3639.2003.tb00003.x [doi]
PST - ppublish
SO  - Brain Pathol. 2003 Jan;13(1):23-33. doi: 10.1111/j.1750-3639.2003.tb00003.x.