PMID- 1258106
OWN - NLM
STAT- MEDLINE
DCOM- 19760520
LR  - 20190727
IS  - 0039-2499 (Print)
IS  - 0039-2499 (Linking)
VI  - 7
IP  - 1
DP  - 1976 Jan-Feb
TI  - Platelet survival studies in stroke-prone spontaneously hypertensive rats 
      (SHRSP).
PG  - 60-4
AB  - Platelet survival was studied by using 51Cr-labeled platelets in stroke-prone 
      spontaneously hypertensive rats (SHRSP), stroke-resistant SHR (SHRSR) and 
      normotensive control rats of the Wistar-Kyoto (WK) strain. Relatively young 
      animals of the same age prior to the development of cerebrovascular lesions 
      (cerebral infarction and/or hemorrhage) were used. Platelet half-life time in 
      SHRSP was slightly but significantly shorter than in any other groups or rats, 
      irrespective of the type of platelet donors. Mean platelet consumption was also 
      significantly increased in SHRSP only. Platelets of SHRSP injected into SHRSR 
      showed normal survival. These data support the concept that the shortened 
      platelet survival in SHRSP is brought about by some extracorpuscular 
      abnormalities. Although the vascular changes in SHRSP could be the most likely 
      explanation for the shortened platelet survival, its mechanism remains to be 
      solved. This investigation suggests that studies of the platelet survival in 
      hypertension may be useful in predicting the development of stroke before its 
      clinical recognition.
FAU - Okuma, M
AU  - Okuma M
FAU - Yamori, Y
AU  - Yamori Y
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Stroke
JT  - Stroke
JID - 0235266
SB  - IM
MH  - Animals
MH  - Blood Platelets/*metabolism
MH  - Blood Pressure
MH  - Cell Survival
MH  - *Disease Models, Animal
MH  - Half-Life
MH  - Hypertension/blood/*genetics
MH  - Male
MH  - Rats
EDAT- 1976/01/01 00:00
MHDA- 1976/01/01 00:01
CRDT- 1976/01/01 00:00
PHST- 1976/01/01 00:00 [pubmed]
PHST- 1976/01/01 00:01 [medline]
PHST- 1976/01/01 00:00 [entrez]
AID - 10.1161/01.str.7.1.60 [doi]
PST - ppublish
SO  - Stroke. 1976 Jan-Feb;7(1):60-4. doi: 10.1161/01.str.7.1.60.