PMID- 12584442
OWN - NLM
STAT- MEDLINE
DCOM- 20030404
LR  - 20171101
IS  - 1424-8581 (Print)
IS  - 1424-8581 (Linking)
VI  - 98
IP  - 1
DP  - 2002
TI  - Characterization of the region containing the jcpk PKD gene on mouse Chromosome 
      10.
PG  - 61-6
AB  - The jcpk gene on mouse Chromosome 10 causes a severe, early onset form of 
      polycystic kidney disease (PKD) when inherited in an autosomal recessive manner. 
      In order to positionally clone this gene, high resolution genetic and radiation 
      hybrid maps were generated along with a detailed physical map of the 
      approximately 500-kb region containing the jcpk gene. Additionally, sixty-nine 
      kidney-specific ESTs were evaluated as candidates for jcpk and subsequently 
      localized throughout the mouse genome by radiation hybrid mapping analysis. 
      Previous studies indicating non-complementation of the jcpk mutation and 67Gso, a 
      new PKD translocation mutant had suggested that 67Gso represents a new allele of 
      jcpk. Fluorescence in situ hybridization (FISH) analysis using key bacterial 
      artificial chromosome clones from the jcpk critical region, refined the 67Gso 
      breakpoint and provided support for the allelism of jcpk and 67Gso.
CI  - Copyright 2002 S. Karger AG, Basel
FAU - Price, S J
AU  - Price SJ
AD  - Joan C. Edwards School of Medicine, Marshall University, Department of 
      Microbiology, Immunology and Molecular Genetics, Huntington, WV 25704, USA.
FAU - Chittenden, L R
AU  - Chittenden LR
FAU - Flaherty, L
AU  - Flaherty L
FAU - O'Dell, B
AU  - O'Dell B
FAU - Guay-Woodford, L M
AU  - Guay-Woodford LM
FAU - Stubbs, L
AU  - Stubbs L
FAU - Bryda, E C
AU  - Bryda EC
LA  - eng
SI  - GENBANK/AA986688
SI  - GENBANK/AI661449
SI  - GENBANK/AI661462
GR  - DK52882/DK/NIDDK NIH HHS/United States
GR  - DK54732/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Switzerland
TA  - Cytogenet Genome Res
JT  - Cytogenetic and genome research
JID - 101142708
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Animals
MH  - *Chromosome Mapping
MH  - Expressed Sequence Tags
MH  - Genes, Recessive
MH  - Genetic Markers
MH  - Humans
MH  - Mice
MH  - Mice, Inbred C3H
MH  - Mice, Inbred C57BL
MH  - Mice, Mutant Strains
MH  - Molecular Sequence Data
MH  - Polycystic Kidney Diseases/*genetics
EDAT- 2003/02/14 04:00
MHDA- 2003/04/05 05:00
CRDT- 2003/02/14 04:00
PHST- 2003/02/14 04:00 [pubmed]
PHST- 2003/04/05 05:00 [medline]
PHST- 2003/02/14 04:00 [entrez]
AID - 68534 [pii]
AID - 10.1159/000068534 [doi]
PST - ppublish
SO  - Cytogenet Genome Res. 2002;98(1):61-6. doi: 10.1159/000068534.