PMID- 12585192
OWN - NLM
STAT- MEDLINE
DCOM- 20031010
LR  - 20161018
IS  - 1003-5370 (Print)
IS  - 1003-5370 (Linking)
VI  - 22
IP  - 6
DP  - 2002 Jun
TI  - [Comparative study of modulating effect of kidney tonifying recipe and spleen 
      invigorating recipe on T-lymphocyte apoptosis in corticosterone treated rats].
PG  - 444-6
AB  - OBJECTIVE: To compare the modulating effect of Kidney tonifying recipe (KTR) and 
      Spleen invigorating recipe (SIR) on T-lymphocyte apoptosis (TLA) in 
      corticosterone treated rats (CTR). METHODS: Qualitative and quantitative analysis 
      on activation-induced TLA was conducted by transmission electron microscope and 
      TUNEL labelled flow cytometry detection. RESULTS: TLA percentage of CTR was 45.87 
      +/- 7.22%, while that of normal control rats was 34.25 +/- 6.47%, the difference 
      between them was significant (P < 0.01). TLA percentage of Youguiyin treated rats 
      was 35.90 +/- 7.39%, and that of Bushen Yishou capsule treated rats was 36.20 +/- 
      9.14%, compared with that of CTR, P < 0.01 and P < 0.05 respectively. TLA 
      percentage of the SIR treated group was 36.92 +/- 11.82%, which was different 
      insignificantly as compared with that of CTR. CONCLUSION: TLA susceptibility was 
      significantly enhanced in CTR. Both KTRs (Youguiyin and Bushen Yishou capsule) 
      had down-regulating effect on TLA, while the effect of SIR was insignificant, 
      suggesting that down-regulating activation-induced TLA may be one of the 
      important mechanisms of KTR in improving T-lymphocyte function in CTR.
FAU - Chen, Yu
AU  - Chen Y
AD  - Institute of Integrated Traditional Chinese and Western Medicine, Huashan 
      Hospital, Fudan University, Shanghai 200040.
FAU - Shen, Zi-yin
AU  - Shen ZY
FAU - Chen, Wei-hua
AU  - Chen WH
LA  - chi
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Zhong Xi Yi Jie He Za Zhi
JT  - Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese 
      journal of integrated traditional and Western medicine
JID - 9211576
RN  - 0 (Drugs, Chinese Herbal)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Animals
MH  - Apoptosis/*drug effects
MH  - Corticosterone
MH  - Drugs, Chinese Herbal/*pharmacology
MH  - Male
MH  - Random Allocation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - T-Lymphocytes/*cytology/ultrastructure
MH  - Yang Deficiency/chemically induced/*immunology
EDAT- 2003/02/15 04:00
MHDA- 2003/10/11 05:00
CRDT- 2003/02/15 04:00
PHST- 2003/02/15 04:00 [pubmed]
PHST- 2003/10/11 05:00 [medline]
PHST- 2003/02/15 04:00 [entrez]
PST - ppublish
SO  - Zhongguo Zhong Xi Yi Jie He Za Zhi. 2002 Jun;22(6):444-6.