PMID- 12586439
OWN - NLM
STAT- MEDLINE
DCOM- 20030530
LR  - 20191106
IS  - 1050-1738 (Print)
IS  - 1050-1738 (Linking)
VI  - 13
IP  - 2
DP  - 2003 Feb
TI  - Leucine/isoleucine zipper coordination of ion channel macromolecular signaling 
      complexes in the heart. Roles in inherited arrhythmias.
PG  - 52-6
AB  - The sympathetic nervous system controls the force and rate of contraction of the 
      heart. The rapid response to stress and exercise mediated by increased 
      sympathetic nervous system (SNS) activity requires the coordinated regulation of 
      several ion channels in response to activation of beta-adrenergic receptors. The 
      microenvironment of target channels is mediated by the assembly of macromolecular 
      signaling complexes in which targeting proteins recruit phosphatases and kinases 
      and in turn bind directly to the channel protein via highly conserved 
      leucine/isoleucine zippers (LIZs). Disruption of local signaling by 
      disease-associated LIZ mutations unbalances the physiologic response to SNS 
      stimulation and increases the risk of arrhythmia in mutation carriers.
FAU - Kass, R S
AU  - Kass RS
AD  - Department of Pharmacology (Division of Cardiology), College of Physicians and 
      Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA. 
      rsk20@columbia.edu
FAU - Kurokawa, J
AU  - Kurokawa J
FAU - Marx, S O
AU  - Marx SO
FAU - Marks, A R
AU  - Marks AR
LA  - eng
GR  - P01 HL 67849/HL/NHLBI NIH HHS/United States
GR  - R01 HL 44365/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Trends Cardiovasc Med
JT  - Trends in cardiovascular medicine
JID - 9108337
RN  - 0 (Ion Channels)
RN  - 0 (Macromolecular Substances)
RN  - 0 (Receptors, Adrenergic, beta)
RN  - 04Y7590D77 (Isoleucine)
SB  - IM
MH  - Arrhythmias, Cardiac/genetics/physiopathology
MH  - Heart/*drug effects/*physiopathology
MH  - Humans
MH  - Ion Channels/*physiology
MH  - Isoleucine/genetics/*physiology
MH  - Leucine Zippers/genetics/*physiology
MH  - Macromolecular Substances
MH  - Myocardial Contraction/physiology
MH  - Receptors, Adrenergic, beta/physiology
MH  - Sympathetic Nervous System/physiopathology
RF  - 46
EDAT- 2003/02/15 04:00
MHDA- 2003/05/31 05:00
CRDT- 2003/02/15 04:00
PHST- 2003/02/15 04:00 [pubmed]
PHST- 2003/05/31 05:00 [medline]
PHST- 2003/02/15 04:00 [entrez]
AID - S1050173802002116 [pii]
AID - 10.1016/s1050-1738(02)00211-6 [doi]
PST - ppublish
SO  - Trends Cardiovasc Med. 2003 Feb;13(2):52-6. doi: 10.1016/s1050-1738(02)00211-6.