PMID- 12586719
OWN - NLM
STAT- MEDLINE
DCOM- 20030912
LR  - 20210915
IS  - 0016-6731 (Print)
IS  - 0016-6731 (Linking)
VI  - 163
IP  - 1
DP  - 2003 Jan
TI  - Genetic and functional analysis of DD44, a sex-linked gene from the dioecious 
      plant Silene latifolia, provides clues to early events in sex chromosome 
      evolution.
PG  - 321-34
AB  - Silene latifolia is a dioecious plant with heteromorphic sex chromosomes. The sex 
      chromosomes of S. latifolia provide an opportunity to study the early events in 
      sex chromosome evolution because of their relatively recent emergence. In this 
      article, we present the genetic and physical mapping, expression analysis, and 
      molecular evolutionary analysis of a sex-linked gene from S. latifolia, DD44 
      (Differential Display 44). DD44 is homologous to the oligomycin 
      sensitivity-conferring protein, an essential component of the mitochondrial ATP 
      synthase, and is ubiquitously expressed in both sexes. We have been able to 
      genetically map DD44 to a region of the Y chromosome that is genetically linked 
      to the carpel-suppressing locus. Although we have physically mapped DD44 to the 
      distal end of the long arm of the X chromosome using fluorescence in situ 
      hybridization (FISH), DD44 maps to the opposite arm of the Y chromosome as 
      determined by our genetic map. These data suggest that chromosomal rearrangements 
      have occurred on the Y chromosome, which may have contributed to the genetic 
      isolation of the Y chromosome. We discuss the implications of these results with 
      respect to the structural and functional evolution of the S. latifolia Y 
      chromosome.
FAU - Moore, Richard C
AU  - Moore RC
AD  - Department of Biology, University of North Carolina, Chapel Hill, North Carolina 
      27599, USA. rcmoore@email.unc.edu
FAU - Kozyreva, Olga
AU  - Kozyreva O
FAU - Lebel-Hardenack, Sabine
AU  - Lebel-Hardenack S
FAU - Siroky, Jiri
AU  - Siroky J
FAU - Hobza, Roman
AU  - Hobza R
FAU - Vyskot, Boris
AU  - Vyskot B
FAU - Grant, Sarah R
AU  - Grant SR
LA  - eng
GR  - 1 F32 GM20891-01/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genetics
JT  - Genetics
JID - 0374636
RN  - 0 (Carrier Proteins)
RN  - 0 (Membrane Proteins)
RN  - EC 3.6.1.- (Adenosine Triphosphatases)
RN  - EC 3.6.3.- (Mitochondrial Proton-Translocating ATPases)
RN  - EC 7.1.2.2 (oligomycin sensitivity-conferring protein)
SB  - IM
MH  - Adenosine Triphosphatases/genetics
MH  - *Biological Evolution
MH  - *Carrier Proteins
MH  - In Situ Hybridization, Fluorescence
MH  - Membrane Proteins/genetics
MH  - Mitochondrial Proton-Translocating ATPases
MH  - Physical Chromosome Mapping
MH  - *Sex Chromosomes
MH  - Silene/*genetics
PMC - PMC1462427
EDAT- 2003/02/15 04:00
MHDA- 2003/09/13 05:00
PMCR- 2003/04/01
CRDT- 2003/02/15 04:00
PHST- 2003/02/15 04:00 [pubmed]
PHST- 2003/09/13 05:00 [medline]
PHST- 2003/02/15 04:00 [entrez]
PHST- 2003/04/01 00:00 [pmc-release]
AID - 10.1093/genetics/163.1.321 [doi]
PST - ppublish
SO  - Genetics. 2003 Jan;163(1):321-34. doi: 10.1093/genetics/163.1.321.