PMID- 12586846
OWN - NLM
STAT- MEDLINE
DCOM- 20030306
LR  - 20190513
IS  - 1079-5006 (Print)
IS  - 1079-5006 (Linking)
VI  - 58
IP  - 2
DP  - 2003 Feb
TI  - Robustness into advanced age of atopy-specific mechanisms in atopy-prone 
      families.
PG  - 99-107
AB  - We evaluated atopy-associated parameters in 1,099 people (aged 6-84 years) from 
      families with history for atopy. All were tested for serum total immunoglobulin E 
      (IgE) and allergen sensitivity by skin prick test. Specific IgE tests were done 
      in randomly selected families. There was a decline with age in serum total IgE 
      values, and relative atopy "incidence rates" were slightly lower among those 
      older than 60 years. However, there was no change with age in sensitivity or 
      severity of atopy. Among those sensitized to ragweed (Ambrosia artemisilfolia), 
      there was no age-associated change in IgE levels specific to Amb a 1, a major 
      allergen extracted from ragweed, and no change in the binding affinity of IgE for 
      the Amb a 1 allergen. Among families with atopic histories, the underlying atopic 
      mechanisms are particularly robust, and the atopic propensity remains into 
      advanced age. In addition, established atopic responses may be focused in an 
      immune system compartment either independent of or minimally influenced by T-cell 
      activity.
FAU - Jackola, Duaine R
AU  - Jackola DR
AD  - The Asthma & Allergy Center, University of Minnesota Medical School, Minneapolis 
      55455, USA. jacko001@umn.edu
FAU - Pierson-Mullany, Lisa K
AU  - Pierson-Mullany LK
FAU - Daniels, Lisa R
AU  - Daniels LR
FAU - Corazalla, Edward
AU  - Corazalla E
FAU - Rosenberg, Andreas
AU  - Rosenberg A
FAU - Blumenthal, Malcolm N
AU  - Blumenthal MN
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Gerontol A Biol Sci Med Sci
JT  - The journals of gerontology. Series A, Biological sciences and medical sciences
JID - 9502837
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Distribution
MH  - Aged
MH  - Aged, 80 and over
MH  - Allergens/pharmacology
MH  - Child
MH  - Cohort Studies
MH  - Dermatitis, Atopic/diagnosis/epidemiology/immunology
MH  - Disease Susceptibility/*epidemiology
MH  - Family
MH  - Female
MH  - Humans
MH  - Hypersensitivity/diagnosis/*epidemiology/*immunology
MH  - Immunoglobulin E/analysis/*immunology
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Patch Tests
MH  - Risk Assessment
MH  - Sampling Studies
MH  - Severity of Illness Index
MH  - Sex Distribution
MH  - T-Lymphocytes/*immunology/physiology
EDAT- 2003/02/15 04:00
MHDA- 2003/03/07 04:00
CRDT- 2003/02/15 04:00
PHST- 2003/02/15 04:00 [pubmed]
PHST- 2003/03/07 04:00 [medline]
PHST- 2003/02/15 04:00 [entrez]
AID - 10.1093/gerona/58.2.b99 [doi]
PST - ppublish
SO  - J Gerontol A Biol Sci Med Sci. 2003 Feb;58(2):99-107. doi: 
      10.1093/gerona/58.2.b99.