PMID- 12586973
OWN - NLM
STAT- MEDLINE
DCOM- 20030411
LR  - 20091103
IS  - 0891-3668 (Print)
IS  - 0891-3668 (Linking)
VI  - 22
IP  - 2
DP  - 2003 Feb
TI  - Absence of associations between influenza-associated encephalopathy and human 
      herpesvirus 6 or human herpesvirus 7.
PG  - 115-9
AB  - BACKGROUND: Influenza-associated encephalopathy is a severe complication of 
      influenza virus infection, but its pathogenesis is unknown. It was recently 
      suggested that the neurologic complications of influenza, including 
      encephalopathy, are associated with human herpesvirus 6 (HHV-6) and human 
      herpesvirus 7 (HHV-7). AIM To confirm or refute the association between 
      influenza-associated encephalopathy and HHV-6 or HHV-7. METHODS: Cerebrospinal 
      fluid and serum from 25 patients with central nervous system complications of 
      influenza (18 patients with encephalopathy and 7 patients with febrile 
      convulsions) were investigated. The specimens were examined by real time 
      polymerase chain reaction (PCR) and nested PCR for HHV-6 and HHV-7 DNA. RESULTS: 
      In the cerebrospinal fluid samples neither HHV-6 DNA nor HHV-7 DNA was detected 
      by real time PCR or nested PCR. HHV-6 DNA was detected in a single serum sample 
      from a patient with febrile convulsions. CONCLUSION: In our study there was no 
      association with HHV-6 or HHV-7 in most patients with central nervous system 
      complications of influenza.
FAU - Kawada, Jun-Ichi
AU  - Kawada J
AD  - Department of Pediatrics, Nagoya University School of Medicine, Japan.
FAU - Kimura, Hiroshi
AU  - Kimura H
FAU - Hara, Shinya
AU  - Hara S
FAU - Ito, Yoshinori
AU  - Ito Y
FAU - Kawashima, Hisashi
AU  - Kawashima H
FAU - Okuno, Toshiomi
AU  - Okuno T
FAU - Morishima, Tsuneo
AU  - Morishima T
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Pediatr Infect Dis J
JT  - The Pediatric infectious disease journal
JID - 8701858
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Age Distribution
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - DNA, Viral/analysis
MH  - Encephalitis, Viral/*complications/virology
MH  - Female
MH  - Herpesviridae Infections/*complications/virology
MH  - Herpesvirus 6, Human/*isolation & purification
MH  - Herpesvirus 7, Human/*isolation & purification
MH  - Humans
MH  - Incidence
MH  - Influenza, Human/*complications/diagnosis
MH  - Japan/epidemiology
MH  - Male
MH  - Polymerase Chain Reaction
MH  - Risk Factors
MH  - Seizures, Febrile/*complications/virology
MH  - Sex Distribution
EDAT- 2003/02/15 04:00
MHDA- 2003/04/12 05:00
CRDT- 2003/02/15 04:00
PHST- 2003/02/15 04:00 [pubmed]
PHST- 2003/04/12 05:00 [medline]
PHST- 2003/02/15 04:00 [entrez]
AID - 10.1097/01.inf.0000050364.08131.48 [doi]
PST - ppublish
SO  - Pediatr Infect Dis J. 2003 Feb;22(2):115-9. doi: 
      10.1097/01.inf.0000050364.08131.48.