PMID- 12588304
OWN - NLM
STAT- MEDLINE
DCOM- 20030904
LR  - 20220310
IS  - 0956-5507 (Print)
IS  - 0956-5507 (Linking)
VI  - 14
IP  - 1
DP  - 2003 Feb
TI  - Abnormal chromosome 8 copy number in cytological smears from breast carcinomas 
      detected by means of fluorescence in situ hybridization (FISH).
PG  - 5-11
AB  - Numerical change in chromosome 8 is an acquired abnormality associated with high 
      clinical stage and may be involved in the conversion of carcinoma in situ in the 
      breast to invasive carcinoma. Fine needle aspiration smears from 53 cases of 
      breast carcinoma were hybridized with centromeric probes for chromosome 8 and the 
      X chromosome. Thirty-eight cases revealed chromosome 8 copy gain. Of the 45 grade 
      II and III tumours, 28 showed polysomy (>3 signals) and six showed trisomy. Of 
      the eight grade I tumours, four were trisomic, none were polysomic. There were 
      only two cases of chromosome 8 copy loss (one each of grade I and III). X 
      chromosome polysomy was also a frequent finding although the signal counts were 
      similar to those for chromosome 8 in only a few cases. Chromosome 8 polysomy 
      occurs frequently in breast carcinoma and high copy number (>3) is associated 
      with high malignancy grade.
FAU - Bofin, A M
AU  - Bofin AM
AD  - Department of Laboratory Medicine, Children's, and Women's Health, The Faculty of 
      Medicine, The Norwegian University of Science and Technology, Trondheim, Norway. 
      anna.bofin@medisin.ntnu.no
FAU - Ytterhus, B
AU  - Ytterhus B
FAU - Fjosne, H E
AU  - Fjosne HE
FAU - Hagmar, B M
AU  - Hagmar BM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Cytopathology
JT  - Cytopathology : official journal of the British Society for Clinical Cytology
JID - 9010345
SB  - IM
MH  - *Aneuploidy
MH  - Breast Neoplasms/*genetics/pathology
MH  - Carcinoma, Ductal, Breast/*genetics/pathology
MH  - Chromosomes, Human, Pair 8/*genetics
MH  - Chromosomes, Human, X/genetics
MH  - Cytodiagnosis/methods
MH  - *Gene Dosage
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence/methods
EDAT- 2003/02/18 04:00
MHDA- 2003/09/05 05:00
CRDT- 2003/02/18 04:00
PHST- 2003/02/18 04:00 [pubmed]
PHST- 2003/09/05 05:00 [medline]
PHST- 2003/02/18 04:00 [entrez]
AID - 1132 [pii]
AID - 10.1046/j.1365-2303.2003.01132.x [doi]
PST - ppublish
SO  - Cytopathology. 2003 Feb;14(1):5-11. doi: 10.1046/j.1365-2303.2003.01132.x.