PMID- 12589169
OWN - NLM
STAT- MEDLINE
DCOM- 20030320
LR  - 20141120
IS  - 0041-1337 (Print)
IS  - 0041-1337 (Linking)
VI  - 75
IP  - 3
DP  - 2003 Feb 15
TI  - Differential immunogenicity of HLA mismatches: HLA-A2 versus HLA-A28.
PG  - 418-20
AB  - The immunogenicity of human leukocyte antigen (HLA)-A2 versus HLA-A28 was 
      analyzed by antibody production, cytotoxic T-lymphocyte (CTL) induction, and 
      graft survival. We observed that an HLA-A2 mismatched child in HLA-A28 women 
      leads to HLA-A2 specific antibodies in 32% of the women (n=31), whereas in the 
      case of an HLA-A28 child and HLA-A2 women (n=30), no HLA-A28 specific antibodies 
      were found ( P<0.002). Also, the CTL precursor frequencies were significantly 
      lower against HLA-A28 compared with CTLp frequencies against HLA-A2 ( P=0.012). 
      Finally, the kidney graft survival was slightly better in HLA-A2 positive 
      recipients transplanted with HLA-A28 mismatches. We can conclude that single 
      HLA-A28 mismatches are less immunogenic in HLA-A2 individuals compared with 
      single HLA-A2 mismatches in HLA-A28 individuals, which is probably because the 
      mismatched epitopes on the HLA-A2 molecule are unique epitopes, whereas the 
      mismatched epitopes on HLA-A28 are shared by other HLA-A and HLA-B molecules.
FAU - Dankers, Marlies K A
AU  - Dankers MK
AD  - Department of Immunohematology and Blood Transfusion, Leiden University Medical 
      Center, Leiden, The Netherlands.
FAU - Roelen, Dave L
AU  - Roelen DL
FAU - Van Der Meer-Prins, Ellen M W
AU  - Van Der Meer-Prins EM
FAU - De Lange, Peter
AU  - De Lange P
FAU - Korfage, Nelleke
AU  - Korfage N
FAU - Smits, Jacqueline M A
AU  - Smits JM
FAU - Persijn, Guido G
AU  - Persijn GG
FAU - Welsh, Ken I
AU  - Welsh KI
FAU - Doxiadis, Ilias I N
AU  - Doxiadis II
FAU - Claas, Frans H J
AU  - Claas FH
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplantation
JT  - Transplantation
JID - 0132144
RN  - 0 (Antibodies)
RN  - 0 (Epitopes)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-A2 Antigen)
RN  - 0 (HLA-A28 antigen)
SB  - IM
MH  - Antibodies/blood
MH  - Epitopes/*immunology
MH  - Female
MH  - Fetus/immunology
MH  - Graft Rejection/*immunology
MH  - Graft Survival/*immunology
MH  - HLA-A Antigens/immunology
MH  - HLA-A2 Antigen/*immunology
MH  - Histocompatibility Testing
MH  - Humans
MH  - In Vitro Techniques
MH  - Kidney Transplantation/*immunology
MH  - Pregnancy
MH  - T-Lymphocytes, Cytotoxic/immunology
EDAT- 2003/02/18 04:00
MHDA- 2003/03/21 04:00
CRDT- 2003/02/18 04:00
PHST- 2003/02/18 04:00 [pubmed]
PHST- 2003/03/21 04:00 [medline]
PHST- 2003/02/18 04:00 [entrez]
AID - 10.1097/01.TP.0000044456.51462.E2 [doi]
PST - ppublish
SO  - Transplantation. 2003 Feb 15;75(3):418-20. doi: 
      10.1097/01.TP.0000044456.51462.E2.