PMID- 12589856
OWN - NLM
STAT- MEDLINE
DCOM- 20030708
LR  - 20190922
IS  - 0385-8146 (Print)
IS  - 0385-8146 (Linking)
VI  - 30
IP  - 1
DP  - 2003 Feb
TI  - Langerhans cell related inflammatory reaction in laryngeal squamous cell 
      carcinoma.
PG  - 81-4
AB  - The major cells involved in cancer cell kill are the T lymphocytes. However, T 
      cells need to be activated upon antigen presentation, which is mediated by the 
      antigen presenting cells, one of which is the Langerhans cell (LC). The purpose 
      of this study was to assess the significance of LC and inflammatory cell 
      infiltration in the laryngeal squamous cell carcinoma (LSCC). Forty-five patients 
      who were operated on for LSCC between 1992 and 1999 were included in the study. 
      The clinical and histopathological features of the patients were reviewed. A 
      semiquantitative estimation of the lymphocyte dominant inflammatory reaction 
      within and around the tumor was performed. Anti S-100 antibodies were used for 
      immunohistochemical detection of LCs. Horseradish peroxidase method was used. LCs 
      were present in almost all of the specimens within and around the tumor tissue. 
      The S-100 results did not associate with grade, T and N stages, tumor stage, 
      laryngeal site of involvement and survival (P>0.05). The S-100 results 
      significantly associated with inflammatory reaction in the tumor tissue (P<0.01). 
      In conclusion, the LC related response is not important to inhibit regional 
      metastasis by cancer cells. The LC is not a reliable tool to determine prognosis 
      of the patients with LSCC in the clinical practice.
FAU - Karakok, Metin
AU  - Karakok M
AD  - Department of Pathology, Faculty of Medicine, Gaziantep University, Kolejtepe, 
      Gaziantep, Turkey.
FAU - Bayazit, Yildirim A
AU  - Bayazit YA
FAU - Ucak, Ramazan
AU  - Ucak R
FAU - Ozer, Enver
AU  - Ozer E
FAU - Kanlikama, Muzaffer
AU  - Kanlikama M
FAU - Mumbuc, Semih
AU  - Mumbuc S
FAU - Sari, Ibrahim
AU  - Sari I
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Auris Nasus Larynx
JT  - Auris, nasus, larynx
JID - 7708170
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (S100 Proteins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Analysis of Variance
MH  - *Antibodies, Monoclonal
MH  - Carcinoma, Squamous Cell/*pathology
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Langerhans Cells/*pathology
MH  - Laryngeal Neoplasms/*pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - S100 Proteins/*analysis
EDAT- 2003/02/19 04:00
MHDA- 2003/07/09 05:00
CRDT- 2003/02/19 04:00
PHST- 2003/02/19 04:00 [pubmed]
PHST- 2003/07/09 05:00 [medline]
PHST- 2003/02/19 04:00 [entrez]
AID - S0385814602000251 [pii]
AID - 10.1016/s0385-8146(02)00025-1 [doi]
PST - ppublish
SO  - Auris Nasus Larynx. 2003 Feb;30(1):81-4. doi: 10.1016/s0385-8146(02)00025-1.