PMID- 12590980
OWN - NLM
STAT- MEDLINE
DCOM- 20031210
LR  - 20190906
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 64
IP  - 3
DP  - 2003 Mar
TI  - A collaborative European search for non-DQA1*05-DQB1*02 celiac disease loci on 
      HLA-DR3 haplotypes: analysis of transmission from homozygous parents.
PG  - 350-8
AB  - The HLA-DQA1*05 with DQB1*02 alleles are a major risk factor for celiac disease 
      (CD). To search for additional human leukocyte antigen (HLA) risk factors, we 
      looked on the DR3-DQ2 risk haplotype, selected because it carries both DQ risk 
      alleles in cis and is the more represented among CD patients. In a European 
      consortium, we identified 109 families with a parent homozygous for 
      DQA1*05-DQB1*02. We typed ten microsatellites in the extended HLA complex, and 
      applied the homozygous-parent transmission disequilibrium test (HPTDT) and 
      extended-TDT to transmissions from homozygous parents. These methods eliminate 
      confounding due to linkage disequilibrium between candidate disease loci and the 
      known risk factor DQA1*05-DQB1*02, and are favorable when sufficient families are 
      available. We did not find evidence of association with any single marker or 
      allele, although weak evidence for additional risk was observed, represented by 
      preferential transmission of six adjacent markers. We tested the largest ever 
      reported HPTDT population in CD, providing unprecedented power. We did not find 
      significant evidence of additional risk-modifying factors on the DR3 haplotype, 
      independent of DQA1*05-DQB1*02, although a weak tendency was observed for the 
      B8-DR3 haplotype. This effect should be tested in large populations with 
      significant representations of both B8-DR3 and non-B8 DR3 haplotypes.
FAU - Louka, Andrew S
AU  - Louka AS
AD  - Institute of Immunology, Rikshospitalet University Hospital, Oslo, Norway.
FAU - Moodie, Simon J
AU  - Moodie SJ
FAU - Karell, Kati
AU  - Karell K
FAU - Bolognesi, Elisabetta
AU  - Bolognesi E
FAU - Ascher, Henry
AU  - Ascher H
FAU - Greco, Luigi
AU  - Greco L
FAU - Momigliano-Richiardi, Patricia
AU  - Momigliano-Richiardi P
FAU - Partanen, Jukka
AU  - Partanen J
FAU - Ciclitira, Paul J
AU  - Ciclitira PJ
FAU - Sollid, Ludvig M
AU  - Sollid LM
CN  - European Genetics Cluster on Celiac Disease
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Genetic Markers)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DR3 Antigen)
SB  - IM
MH  - Celiac Disease/*genetics
MH  - Female
MH  - Genetic Markers
MH  - Genetic Predisposition to Disease
MH  - HLA-DQ Antigens/genetics
MH  - HLA-DR3 Antigen/*genetics
MH  - Haplotypes/*genetics
MH  - *Homozygote
MH  - Humans
MH  - Male
MH  - Microsatellite Repeats
EDAT- 2003/02/20 04:00
MHDA- 2003/12/12 05:00
CRDT- 2003/02/20 04:00
PHST- 2003/02/20 04:00 [pubmed]
PHST- 2003/12/12 05:00 [medline]
PHST- 2003/02/20 04:00 [entrez]
AID - S0198885902008224 [pii]
AID - 10.1016/s0198-8859(02)00822-4 [doi]
PST - ppublish
SO  - Hum Immunol. 2003 Mar;64(3):350-8. doi: 10.1016/s0198-8859(02)00822-4.