PMID- 12590984
OWN - NLM
STAT- MEDLINE
DCOM- 20031210
LR  - 20190906
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 64
IP  - 3
DP  - 2003 Mar
TI  - Distribution of MICA alleles and haplotypes associated with HLA in the Korean 
      population.
PG  - 378-84
AB  - The MICA (MHC class I chain-related gene A) is a polymorphic gene located 46 kb 
      centromeric of the HLA-B gene, and is preferentially expressed in epithelial 
      cells and intestinal mucosa. The MICA gene, similar to human leukocyte antigen 
      (HLA) class I, displays a high degree of genetic polymorphism in exons 2, 3, 4, 
      and 5, amounting to 54 alleles. In this study, we investigated the polymorphisms 
      at exons coding for extracellular domains (exons 2, 3, and 4), and the GCT repeat 
      polymorphism at the transmembrane (exon 5) of MICA in 199 unrelated healthy 
      Koreans. Eight alleles were observed in the Korean population, with allele 
      frequencies for MICA*010, MICA*00201, MICA*027, MICA*004, MICA*012, MICA*00801, 
      MICA*00901, and MICA*00701 being 18.3%, 17.8%, 13.6%, 12.3%, 11.1%, 10.8%, 10.6%, 
      and 3.3%, respectively. Strong linkage disequilibria were also observed between 
      the MICA and HLA-B gene-MICA*00201-B58, MICA*004-B44, MICA*00701-B27, 
      MICA*00801-B60, MICA*00901-B51, MICA*010-B62, MICA*012-B54, and MICA*027-B61. In 
      the analysis of the haplotypes of HLA class I genes (HLA-A, B, and C) and the 
      MICA, the most common haplotype was MICA*004-A33-B44-Cw*07, followed by 
      MICA*00201-A2-B58-Cw*0302 and MICA*012-A2-B54-Cw*0102. The MICA null haplotype 
      might be identified in the HLA-B48 homozygous individual. These results will 
      provide an understanding of the role of MICA in transplantation, disease 
      association, and population analyses in Koreans.
FAU - Pyo, Chul-Woo
AU  - Pyo CW
AD  - Department of Microbiology, College of Medicine, The Catholic University of 
      Korea, Seoul, South Korea.
FAU - Hur, Seong-Suk
AU  - Hur SS
FAU - Kim, Yang-Kyum
AU  - Kim YK
FAU - Choi, Hee-Baeg
AU  - Choi HB
FAU - Kim, Tae-Yoon
AU  - Kim TY
FAU - Kim, Tai-Gyu
AU  - Kim TG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (MHC class I-related chain A)
SB  - IM
MH  - *Gene Frequency
MH  - *Haplotypes
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Korea/epidemiology
MH  - Trinucleotide Repeats
EDAT- 2003/02/20 04:00
MHDA- 2003/12/12 05:00
CRDT- 2003/02/20 04:00
PHST- 2003/02/20 04:00 [pubmed]
PHST- 2003/12/12 05:00 [medline]
PHST- 2003/02/20 04:00 [entrez]
AID - S0198885902008261 [pii]
AID - 10.1016/s0198-8859(02)00826-1 [doi]
PST - ppublish
SO  - Hum Immunol. 2003 Mar;64(3):378-84. doi: 10.1016/s0198-8859(02)00826-1.