PMID- 12591112
OWN - NLM
STAT- MEDLINE
DCOM- 20030702
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 462
IP  - 1-3
DP  - 2003 Feb 21
TI  - Combined action of vasoactive amines and bradykinin mediates allergen-evoked 
      thermal hyperalgesia in rats.
PG  - 185-92
AB  - The ability of allergens to induce hyperalgesia in immunoglobulin E 
      (IgE)-sensitized rats was investigated. The left hind paws of Wistar rats were 
      sensitized with intraplantar injections of IgE anti-dinitrophenylated bovine 
      serum albumin monoclonal antibody, and challenged with dinitrophenylated bovine 
      serum albumin 24 h later. Allergen challenge yielded rapid thermal hyperalgesia 
      and oedema formation in the ipsilateral paws, both reaching a plateau from 15 min 
      to 3 h, and both diminishing thereafter. Allergen-evoked hyperalgesia was 
      inhibited by intraperitoneal treatment with meclizine or methysergide, histamine 
      and 5-hydroxytryptamine receptor antagonists. There was also sensitivity to local 
      treatment with either bradykinin B(1) or B(2) receptor antagonists, 
      des-Arg(9)-[Leu(8)]-bradykinin or D-arginyl-[Hyp3, Thi5, D-Tic7, Oic8]-bradykinin 
      (Hoe 140). Anaphylactic hyperalgesia was mimicked by the combined administration 
      of histamine, 5-hydroxytryptamine and bradykinin at doses which were ineffective 
      when injected alone. This synergistic effect was abolished by treatment with 
      either meclizine, methysergide, Hoe 140 or des-Arg(9)-[Leu(8)]-bradykinin. Our 
      findings show that local thermal hyperalgesia is a feature of allergen-evoked 
      inflammation, and that a synergistic interaction among bradykinin, 
      5-hydroxytryptamine and histamine plays a critical role in this phenomenon.
FAU - Lavich, Tatiana R
AU  - Lavich TR
AD  - Departamento de Fisiologia e Farmacodinamica, Instituto Oswaldo Cruz-FIOCRUZ, Av. 
      Brasil 4365, Caixa Postal 926, Rio de Janeiro, Brazil.
FAU - Cordeiro, Renato S B
AU  - Cordeiro RS
FAU - Calixto, Joao B
AU  - Calixto JB
FAU - e Silva, Patricia M R
AU  - e Silva PM
FAU - Martins, Marco A
AU  - Martins MA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Allergens)
RN  - 0 (Bradykinin Receptor Antagonists)
RN  - 0 (Dinitrophenols)
RN  - 0 (Histamine H1 Antagonists)
RN  - 0 (Serotonin Antagonists)
RN  - 27432CM55Q (Serum Albumin, Bovine)
RN  - 2YHB6175DO (Cyproheptadine)
RN  - 333DO1RDJY (Serotonin)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 3L5TQ84570 (Meclizine)
RN  - 64695-06-3 (bradykinin, Leu(8)-des-Arg(9)-)
RN  - 7PG89G35Q7 (icatibant)
RN  - 820484N8I3 (Histamine)
RN  - S8TIM42R2W (Bradykinin)
RN  - XZA9HY6Z98 (Methysergide)
SB  - IM
MH  - Allergens/immunology
MH  - Animals
MH  - Bradykinin/*administration & dosage/*analogs & derivatives/pharmacology
MH  - Bradykinin Receptor Antagonists
MH  - Cyproheptadine/pharmacology
MH  - Dinitrophenols/metabolism
MH  - Dose-Response Relationship, Drug
MH  - Drug Synergism
MH  - Edema/chemically induced/prevention & control
MH  - Histamine/*administration & dosage
MH  - Histamine H1 Antagonists/pharmacology
MH  - Hyperalgesia/*chemically induced/immunology/prevention & control
MH  - Immunoglobulin E/immunology
MH  - Male
MH  - Meclizine/pharmacology
MH  - Methysergide/pharmacology
MH  - Pain/chemically induced/immunology/prevention & control
MH  - Rats
MH  - Rats, Wistar
MH  - Serotonin/*administration & dosage
MH  - Serotonin Antagonists/pharmacology
MH  - Serum Albumin, Bovine/administration & dosage/metabolism
MH  - Time Factors
EDAT- 2003/02/20 04:00
MHDA- 2003/07/03 05:00
CRDT- 2003/02/20 04:00
PHST- 2003/02/20 04:00 [pubmed]
PHST- 2003/07/03 05:00 [medline]
PHST- 2003/02/20 04:00 [entrez]
AID - S0014299902029473 [pii]
AID - 10.1016/s0014-2999(02)02947-3 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2003 Feb 21;462(1-3):185-92. doi: 10.1016/s0014-2999(02)02947-3.