PMID- 12592818
OWN - NLM
STAT- MEDLINE
DCOM- 20030320
LR  - 20201208
IS  - 0024-3477 (Print)
IS  - 0024-3477 (Linking)
VI  - 124 Suppl 1
DP  - 2002 Sep
TI  - [Gastroesophageal reflux disease and Helicobacter pylori infection].
PG  - 52-6
AB  - Gastroesophageal reflux disease (GERD) is one of the common diseases of the upper 
      gastrointestinal system. It is present in the whole world population, especially 
      frequent in the developed countries. It evolves from pathological reflux which 
      exposes the esophagus to the gastric contents which must overcome esophageal 
      defense system. Many factors have been found to be involved in the pathogenesis 
      of GERD; the most important one is the relaxation of the lower esophageal 
      sphincter. Intensity of the disease is proportional to the amount of gastric 
      contents refluxing from the stomach and the duration of esophageal exposure to 
      this contents. GERD is currently in the spotlight because of its special 
      significance in the development of very specific disease in the lower part of the 
      esophagus--Barrett's esophagus, as well as esophageal adenocarcinoma which has 
      lately been increasing in prevalence. Today, unrecognized and inadequately cured 
      GERD is known to be a high risk factor for adenocarcinoma of the esophagus. In 
      recent years the relation between GERD and Helicobacter pylori infection has been 
      the topic of investigation by many prominent researchers. Therapy of GERD is 
      based on inhibition of acid secretion. There are many different therapeutic 
      agents available, however, proton pump inhibitors (PPI) are considered to be the 
      most effective in the treatment of this disease.
FAU - Naumovski-Mihalic, Slavica
AU  - Naumovski-Mihalic S
AD  - Klinicka bolnica Merkur Medicinskog fakulteta Sveucilista u Zagrebu.
FAU - Sabaric, Branka
AU  - Sabaric B
FAU - Filipec, Tajana
AU  - Filipec T
FAU - Ticak, Mirjana
AU  - Ticak M
FAU - Prskalo, Marija
AU  - Prskalo M
FAU - Skurla, Bruno
AU  - Skurla B
FAU - Papa, Branko
AU  - Papa B
FAU - Dominis, Mara
AU  - Dominis M
FAU - Katicic, Miroslava
AU  - Katicic M
LA  - pol
PT  - Journal Article
TT  - Gastroezofagealna refluksna bolest i infekcija Helicobacterom pylori.
PL  - Croatia
TA  - Lijec Vjesn
JT  - Lijecnicki vjesnik
JID - 0074253
SB  - IM
MH  - Adenocarcinoma/etiology
MH  - Barrett Esophagus/etiology
MH  - Esophageal Neoplasms/etiology
MH  - Female
MH  - Gastroesophageal Reflux/diagnosis/drug therapy/*microbiology/physiopathology
MH  - *Helicobacter Infections/diagnosis/drug therapy
MH  - *Helicobacter pylori
MH  - Humans
MH  - Male
MH  - Middle Aged
EDAT- 2003/02/21 04:00
MHDA- 2003/03/21 04:00
CRDT- 2003/02/21 04:00
PHST- 2003/02/21 04:00 [pubmed]
PHST- 2003/03/21 04:00 [medline]
PHST- 2003/02/21 04:00 [entrez]
PST - ppublish
SO  - Lijec Vjesn. 2002 Sep;124 Suppl 1:52-6.