PMID- 12593498
OWN - NLM
STAT- MEDLINE
DCOM- 20030305
LR  - 20170214
IS  - 0003-3197 (Print)
IS  - 0003-3197 (Linking)
VI  - 54
IP  - 1
DP  - 2003 Jan
TI  - Increased immunoglobulin E response in acute coronary syndromes.
PG  - 73-9
AB  - The role of inflammation and mast cell activation has been implicated in 
      atherosclerotic plaque destabilization and rupture. To investigate the role of 
      immunoglobulin E (IgE) in acute coronary syndrome, a prospective clinical study 
      was conducted in patients with acute myocardial infarction (AMI), unstable angina 
      pectoris (UAP), stable angina pectoris (SAP), and healthy controls. IgE levels 
      were serially measured and compared in consecutive patients with AMI (n = 16) and 
      UAP (n = 14) on days 1, 3, 7, 21 after admission and 3 months later and only once 
      in stable angina pectoris (n = 15) and healthy controls (n = 14). In addition, 
      blood eosinophil and basophil levels on admission were measured in all groups and 
      compared. Initial IgE levels determined at admission in patients with AMI, UAP, 
      and SAP were significantly higher than levels in the control group (p = 0.002). 
      Initial high IgE level in AMI on day 1 increased to a peak by day 7 (p = 0.024), 
      then gradually decreased by day 21 and at 3 months (p = 0.052). High IgE level in 
      UAP persisted by day 7 and gradually decreased by day 21 and 3 months (p = 0.037 
      and p = 0.018, respectively). Blood eosinophil count on admission was 
      significantly higher in UAP than in the control group (p = 0.005). Basophil 
      levels of both AMI and UAP groups on admission were found to be elevated as 
      opposed to control group (p = 0.02 and p = 0.012, respectively). This study 
      demonstrates that the level of IgE significantly increased during the acute phase 
      of acute coronary syndromes and gradually decreased, supporting the role of acute 
      inflammatory response and mast cell involvement in plaque rupture.
FAU - Erdogan, Okan
AU  - Erdogan O
AD  - Department of Cardiology, School of Medicine, Trakya University, Edirne, Turkey. 
      okanerdogan@yahoo.com
FAU - Gul, Cetin
AU  - Gul C
FAU - Altun, Armagan
AU  - Altun A
FAU - Ozbay, Gultac
AU  - Ozbay G
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Controlled Clinical Trial
PT  - Journal Article
PL  - United States
TA  - Angiology
JT  - Angiology
JID - 0203706
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Acute Disease
MH  - Acute-Phase Reaction/*blood/etiology/*physiopathology
MH  - Aged
MH  - Angina Pectoris/*blood/complications/*physiopathology
MH  - Angina, Unstable/*blood/complications/*physiopathology
MH  - Basophils/physiology
MH  - Eosinophils/physiology
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood/*physiology
MH  - Leukocyte Count
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*blood/complications/*physiopathology
MH  - Prospective Studies
MH  - Syndrome
MH  - Time Factors
EDAT- 2003/02/21 04:00
MHDA- 2003/03/06 04:00
CRDT- 2003/02/21 04:00
PHST- 2003/02/21 04:00 [pubmed]
PHST- 2003/03/06 04:00 [medline]
PHST- 2003/02/21 04:00 [entrez]
AID - 10.1177/000331970305400109 [doi]
PST - ppublish
SO  - Angiology. 2003 Jan;54(1):73-9. doi: 10.1177/000331970305400109.