PMID- 12595088
OWN - NLM
STAT- MEDLINE
DCOM- 20030708
LR  - 20190610
IS  - 0006-3002 (Print)
IS  - 0006-3002 (Linking)
VI  - 1620
IP  - 1-3
DP  - 2003 Mar 17
TI  - Effects of 50-Hz magnetic fields on the signalling pathways of fMLP-induced shape 
      changes in invertebrate immunocytes: the activation of an alternative "stress 
      pathway".
PG  - 185-90
AB  - N-formyl-Meth-Leu-Phe (fMLP)-induced immunocyte shape changes in the mussel 
      Mytilus galloprovincialis through both the phosphatidylinositol and the cAMP 
      pathways are studied. Fifteen- and thirty-minute exposures of mussels to 50-Hz 
      magnetic fields (MFs) at intensities of 300 and 400 microT do not provoke 
      permanent cell damage, since immunocytes maintain the capacity to respond to 
      fMLP. This avoidance of external insult seems to be achieved through the 
      activation of a "stress pathway" which is not functionally detectable in 
      nonexposed animals and which involves mitogen activated protein (MAP) kinase 
      members. This phenomenon is clearly evident at 400 microT. Contemporaneously, a 
      different expression of Jun transcriptional regulatory proteins is also found.
FAU - Malagoli, Davide
AU  - Malagoli D
AD  - Department of Animal Biology, University of Modena and Reggio Emilia, via Campi 
      213/D, Italy.
FAU - Gobba, Fabriziomaria
AU  - Gobba F
FAU - Ottaviani, Enzo
AU  - Ottaviani E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Biochim Biophys Acta
JT  - Biochimica et biophysica acta
JID - 0217513
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Proto-Oncogene Proteins c-jun)
RN  - 59880-97-6 (N-Formylmethionine Leucyl-Phenylalanine)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
SB  - IM
MH  - Animals
MH  - Cell Size/drug effects
MH  - *Electromagnetic Fields
MH  - Enzyme Activation
MH  - Enzyme Inhibitors/pharmacology
MH  - Image Processing, Computer-Assisted
MH  - Immunoblotting
MH  - Mitogen-Activated Protein Kinases/antagonists & inhibitors/*chemistry
MH  - *Mollusca/cytology/drug effects
MH  - N-Formylmethionine Leucyl-Phenylalanine
MH  - Proto-Oncogene Proteins c-jun/analysis
MH  - Signal Transduction
EDAT- 2003/02/22 04:00
MHDA- 2003/07/09 05:00
CRDT- 2003/02/22 04:00
PHST- 2003/02/22 04:00 [pubmed]
PHST- 2003/07/09 05:00 [medline]
PHST- 2003/02/22 04:00 [entrez]
AID - S0304416502005317 [pii]
AID - 10.1016/s0304-4165(02)00531-7 [doi]
PST - ppublish
SO  - Biochim Biophys Acta. 2003 Mar 17;1620(1-3):185-90. doi: 
      10.1016/s0304-4165(02)00531-7.