PMID- 12595587
OWN - NLM
STAT- MEDLINE
DCOM- 20030827
LR  - 20111117
IS  - 0031-3998 (Print)
IS  - 0031-3998 (Linking)
VI  - 53
IP  - 3
DP  - 2003 Mar
TI  - Relation of streptococcal pyrogenic exotoxin C as a causative superantigen for 
      Kawasaki disease.
PG  - 403-10
AB  - We previously reported that the frequency of TCRBV2 and TCRBV6S5-bearing T-cells 
      was high in patients in the acute phase of Kawasaki disease (KD) and that 
      streptococcal pyrogenic exotoxin C (SPE-C) was a potent stimulator of these 
      TCRBV-bearing T-cells. To further elucidate the pathogenesis of KD, we examined 
      the T-cell receptor (TCR) repertoire, human leukocyte antigen (HLA)-DRB1 
      genotype, and antibody responses to recombinant(r) SPE-C in patients with KD. We 
      also performed in vitro stimulation with rSPE-A and rSPE-C of peripheral blood 
      mononuclear cells from healthy donors and characterized the reacting T-cells. The 
      percentage of T-cells bearing TCRBV2 and TCRBV6S5 was high in patients in the 
      acute stage of KD. rSPE-C stimulation of PBMC from healthy donors induced 
      expansion of TCRBV2 and TCRBV6S5-bearing T-cells. Furthermore, serum levels of 
      anti-SPEC antibodies, which did not display antimitogenic activity, were higher 
      in patients with acute KD than in age-matched controls. The frequencies of the 
      DRB1*04051, 0406, and 0901 were high, whereas that of the DRB1*1101 was low among 
      patients with KD as compared with the healthy adults.
FAU - Yoshioka, Takeshi
AU  - Yoshioka T
AD  - Shionogi Discovery Research Laboratories, Shionogi & Co, Ltd, Osaka-city, Osaka 
      533, Japan. takeshi.yoshioka@shionogi.co.jp
FAU - Matsutani, Takaji
AU  - Matsutani T
FAU - Toyosaki-Maeda, Tomoko
AU  - Toyosaki-Maeda T
FAU - Suzuki, Hiroyuki
AU  - Suzuki H
FAU - Uemura, Sigeru
AU  - Uemura S
FAU - Suzuki, Ryuji
AU  - Suzuki R
FAU - Koike, Michio
AU  - Koike M
FAU - Hinuma, Yorio
AU  - Hinuma Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Pediatr Res
JT  - Pediatric research
JID - 0100714
RN  - 0 (Antibodies, Bacterial)
RN  - 0 (Bacterial Proteins)
RN  - 0 (Exotoxins)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Membrane Proteins)
RN  - 0 (SpeA protein, Streptococcus pyogenes)
RN  - 0 (Superantigens)
RN  - 0 (erythrogenic toxin)
SB  - IM
MH  - Antibodies, Bacterial/blood
MH  - *Bacterial Proteins
MH  - Child, Preschool
MH  - Exotoxins/*analysis/immunology
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - HLA-DR Antigens/genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Infant
MH  - Male
MH  - *Membrane Proteins
MH  - Mucocutaneous Lymph Node Syndrome/genetics/*immunology/*microbiology
MH  - Streptococcal Infections/*complications/genetics/*immunology
MH  - Superantigens/analysis/immunology
MH  - T-Lymphocytes/microbiology
EDAT- 2003/02/22 04:00
MHDA- 2003/08/28 05:00
CRDT- 2003/02/22 04:00
PHST- 2003/02/22 04:00 [pubmed]
PHST- 2003/08/28 05:00 [medline]
PHST- 2003/02/22 04:00 [entrez]
AID - 10.1203/01.PDR.0000049668.54870.50 [doi]
PST - ppublish
SO  - Pediatr Res. 2003 Mar;53(3):403-10. doi: 10.1203/01.PDR.0000049668.54870.50.