PMID- 12596070
OWN - NLM
STAT- MEDLINE
DCOM- 20030422
LR  - 20061115
IS  - 0945-6317 (Print)
IS  - 0945-6317 (Linking)
VI  - 442
IP  - 2
DP  - 2003 Feb
TI  - Pulmonary metastases from a low-grade endometrial stromal sarcoma confirmed by 
      chromosome aberration and fluorescence in-situ hybridization approaches: a case 
      of recurrence 13 years after hysterectomy.
PG  - 173-8
AB  - Pulmonary metastasis from low-grade endometrial stromal sarcomas (ESSs) 
      occasionally are found after long, disease-free periods, mostly as incidental 
      histological or radiological discoveries. We describe a case of low-grade ESS 
      presenting as nodular pulmonary metastases finally diagnosed by estrogen-receptor 
      staining, cytogenetic and fluorescence in situ hybridization (FISH) analyses, and 
      perusal of the histology of hysterectomy material. An abnormal nodule in the lung 
      field was discovered by means of chest X-ray of a 47-year-old woman. She had been 
      disease free for 13 years after hysterectomy for an alleged leiomyoma. A computed 
      tomographic scan revealed nodules, with fluctuation in size over the 2-year 
      period, in both lungs. Finally the lesion in the left lung was resected, and 
      pulmonary endometriosis was suspected because of the lack of stromal cell nuclear 
      atypia and positive immunohistochemical reactions for estrogen and progesterone 
      receptors. However, a characteristic karyotype was identified cytogenetically: 
      46, XX, t(7;17)(p15;q11), the translocation of which, specific to ESS, was 
      confirmed by FISH analysis. A final diagnosis of pulmonary metastases from an ESS 
      could be made by reviewing the histology of the previous uterine tumor. In this 
      case, metastatic lesions from an ESS showed a decrease as well as an increase in 
      size, despite the malignant potential. Immunostaining for estrogen and 
      progesterone receptors and cytogenetic and FISH analyses, together with clinical 
      information on the past gynecological history, are valuable diagnostic keys.
FAU - Satoh, Yukitoshi
AU  - Satoh Y
AD  - Department of Pathology, the JFCR Cancer Institute, 1-37-1 Kami-ikebukuro, 
      Toshima-ku, Tokyo 170-8455, Japan. ysatoh@jfcr.or.jp
FAU - Ishikawa, Yuichi
AU  - Ishikawa Y
FAU - Miyoshi, Tatsu
AU  - Miyoshi T
FAU - Mukai, Hiroyuki
AU  - Mukai H
FAU - Okumura, Sakae
AU  - Okumura S
FAU - Nakagawa, Ken
AU  - Nakagawa K
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20021126
PL  - Germany
TA  - Virchows Arch
JT  - Virchows Archiv : an international journal of pathology
JID - 9423843
RN  - 0 (Receptors, Estrogen)
RN  - 0 (Receptors, Progesterone)
SB  - IM
MH  - Chromosomes, Human, Pair 17
MH  - Chromosomes, Human, Pair 7
MH  - Endometrial Stromal Tumors/chemistry/genetics/*pathology
MH  - Female
MH  - Humans
MH  - Leiomyosarcoma/chemistry/genetics/*secondary
MH  - Lung Neoplasms/chemistry/genetics/*secondary
MH  - Middle Aged
MH  - Receptors, Estrogen/analysis
MH  - Receptors, Progesterone/analysis
MH  - Spectral Karyotyping
MH  - Translocation, Genetic
EDAT- 2003/02/22 04:00
MHDA- 2003/04/23 05:00
CRDT- 2003/02/22 04:00
PHST- 2002/06/10 00:00 [received]
PHST- 2002/09/26 00:00 [accepted]
PHST- 2003/02/22 04:00 [pubmed]
PHST- 2003/04/23 05:00 [medline]
PHST- 2003/02/22 04:00 [entrez]
AID - 10.1007/s00428-002-0731-9 [doi]
PST - ppublish
SO  - Virchows Arch. 2003 Feb;442(2):173-8. doi: 10.1007/s00428-002-0731-9. Epub 2002 
      Nov 26.